Navegando por Palavras-chave "Aging skin"

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    Comparação das medidas instrumentais não invasivas e parâmetros clínicos entre o envelhecimento intrínseco e o fotoenvelhecimento da pele dos antebraços
    (Universidade Federal de São Paulo (UNIFESP), 2017-04-28) Carvalho, Paula Roberta Silva de [UNIFESP]; Bagatin, Edileia [UNIFESP]; http://lattes.cnpq.br/6478900066830476; http://lattes.cnpq.br/5342802165966201; Universidade Federal de São Paulo (UNIFESP)
    Background: The intrinsic and extrinsic skin aging present biomechanical and morphological differences, which are reflected in the appearance of roughness, superficial and deep wrinkles, atrophy, reduced elasticity, hypo- and hyperpigmentation and actinic keratosis. The photodamage causes accentuation of all these features and increases the risk for development of premalignant lesions (actinic keratosis) and malignant (basal and squamous cell carcinomas). Objective: to evaluate and compare the characteristics of the flexor (with a predominance of intrinsic aging) and extensor (chronically exposed to sunlight area and other environmental factors, with a predominance of extrinsic aging or photoaging) skin surfaces of the forearms. Methods: The cross-sectional study of diagnostic interventions, including 23 females, aged over 60 years. The extensor and flexor faces of right and left forearms were compared in relation to clinical parameters and non-invasive instrumental measures, such as: skin surface (profilometry), viscoelastic properties, hydration (corneometry) as well as dermal thickness and echogenicity (ultrasound). Results: The water content in the corneal layer showed a significant difference as the flexor area showed an average value greater than the extensor face. The average of the measurements obtained by high-frequency ultrasound showed difference between the faces. The skin surface measurements showed significant differences when compared roughness and desquamation of the extensor and flexor faces on both forearms, but for the flexor face, the differences were smaller. Regarding the wrinkles depth, there was a significant difference of average between the evaluated faces only for the left forearm (p = 0.017), once the flexor face presented an average value greater than the extensor. There was no significant correlation between measurements of the aqueous content of the corneal layer and the viscoelastic properties of the skin, as well as among those obtained by ultrasound. In the prophylometry, only the scaling presented a negative correlation with the corneometry. The visco-elastic properties of the skin showed a positive correlation between the faces. The measurements obtained by the ultrasound and the visco-elastic properties of the skin showed a positive correlation in the flexor face. In the extensor face, there was a positive correlation between roughness, scaliness and wrinkle depth. In the flexor face, the depth of the wrinkles presented negative correlation with a dermal thickness. Dermal density showed negative correlation with other ultrasound measurements. These results were in agreement with established clinical parameters such as wrinkles, elastosis, decreased elasticity and water content, demonstrating the differences between photoaging and chronological aging. Conclusion: Significant differences in the biophysical characteristics of the extensor and flexor surfaces of the forearms were detected. The non-invasive instrumental measures were positively correlated with clinical findings. We concluded that they are useful tools for the evaluation of photoaging and chronological aging in clinical research, as efficacy and safety parameters.
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    Crema para la piel con factor de crecimiento epidermico oligopéptido -1
    (Universidade Federal de São Paulo (UNIFESP), 2017-10-09) Medina Mendonza, Maira Eugenia [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Blanes, Leila [UNIFESP]; http://lattes.cnpq.br/1898450330418640; http://lattes.cnpq.br/1619822351741819; http://lattes.cnpq.br/2191877318404296; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Over time the skin loses firmness and elasticity due to the loss of not only collagen and elastin, but also epidermal growth factor. For this reason in the present study it was proposed to develop a skin cream where the epidermal growth factor is the active principle. Objective: to develop a skin cream with Epidermal Growth Factor (EGF) Oligopeptide1. Method: Exploratory and descriptive investigation whose search was carried out in the databases Pubmed, Scielo, National Institute of Industrial Property (INPI), Espacenet, Wipo and Google Patents. The cream has been manipulated from the active principle, the epidermal growth factor olipéptico-1. Next, preliminary tests of thermal and accelerated and microbiological stability of the cream were performed to recognize and analyze the factors that could accelerate or delay alterations in these parameters. Results: Four patents were found where FCE was used for tissue regeneration, but none was used as the only active ingredient to counteract signs of skin aging. Preliminary study approved the formula in terms of appearance, odor and volume, within the product considered cosmetic and was determined pH of 5.67 and density of 1.0483g / ml. A skin cream with FCE Oligopeptide-1, white viscose, free of lumps, was then made with Polybase CT-20%; Octyl Palmitate - 5%; Softisan 649-5%; Glycerin - 2%; Cetiol 868-2%; Edta - 0.2%; Henoxetol -1%; BHT - 0.05%; Flower Essence of Plum - 1%; Nano Water osmosis qsp - 60ml and FCE - 3%. Physical-chemical, organoleptic and microbiological stability tests were appropriated and approved. Conclusion: A skin cream with FCE oligopéptido-1 has been developed.
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    Estudo clínico-laboratorial para verificar e comparar eficácia e segurança do ácido retinoico a 0,05% em creme e a 5% em peelings superficiais no fotoenvelhecimento e carcinogênese do antebraço
    (Universidade Federal de São Paulo (UNIFESP), 2017-10-26) Sumita, Juliana Mayumi [UNIFESP]; Bagatin, Edileia [UNIFESP]; Miot, Hélio Amante [UNIFESP]; http://lattes.cnpq.br/2543633050941005; Universidade Federal de São Paulo (UNIFESP)
    Background: Topical use of retinoic acid in cream is the gold standard treatment for skin aging, particularly photoaging. To obtain the same results in less time, the peeling of retinoic acid was created, but there are few controlled studies on its effectiveness, limited to the improvement of the signs of photoaging and cutaneous hyperpigmentation. Objectives: Evaluate and compare efficacy and safety of retinoic acid at 0.05% and 5% (as a peeling agent) for photoaging and carcinogenesis of the forearm. Methods: Prospective clinical study of therapeutic intervention, randomized, comparative and evaluator blinded. Efficacy and safety evaluated by the participant's opinion, severity of photoaging, measurement of the viscoelastic properties of the skin, corneometry, profilometry, high frequency ultrasound, histological exams (Hematoxylin-Eosin and Verhoeff stainings) and immunohistochemistry (p53, bcl-2 , Ki67 and collagen I). Results: The two forearms of 24 participants were evaluated. Three efficacy parameters showed opposite effects of the two treatments. 1) The thickness of the stratum corneum decreased with 0.05% retinoic acid and increased with 5%. 2) The echogenicity of the dermis by ultrasonography increased with 0.05% and decreased with 5%. 3) Ki67 expression increased with 0.05% and decreased with 5%. The favorable opinion of the participant, improvement of the photoaging score, corneometry, profilometry, recovery of viscoelasticity, increase of papillary dermis thickness, reduction of solar elastosis, decrease of p53, increase of bcl-2 and collagen I were not different between them. There was good tolerability in both treatments. Conclusion: The results confirmed the safety and benefits of retinoic acid at 0.05% and 5%, but at different scopes. 0.05% retinoic acid reversed the signs of photoaging in the long term (elevation of the echogenicity of the dermis), reaffirming itself as a gold standard for the treatment of photoaging. Peeling of 5% retinoic acid reduced the risk of skin cancer in the short term (reduction of Ki67), and was shown as a promising method for adjuvant treatment of actinic keratoses and cancerization field.