Effects of Pre or Posttraining Dorsal Hippocampus D-AP5 Injection on Fear Conditioning to Tone, Background, and Foreground Context
Data
2008-01-01
Autores
Schenberg, Eduardo Ekman 
Menezes Oliveira, Maria Gabriela
Tipo
Artigo
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Resumo
NMDA receptor antagonist D-AP5 was injected into the dorsal hippocampus of Wistar rats before or immediately after the training session in fear conditioning. Training was conducted both with signaled (background context) or unsignaled (foreground context) footshocks. Contextual fear conditioning was assessed 24 h later and tone fear conditioning 48 h after training (only in the signaled footshock condition). Pretraining injections impaired conditioned fear to contextual features, both in background and foreground configurations, whereas tone fear conditioning was left intact. Posttraining injections were ineffective in all cases. We conclude that dorsal hippocampal NMDA receptors are required for contextual fear acquisition independently of context saliency and that they are not required to early consolidation processes. (C) 2008 Wiley-Liss, Inc.
Descrição
Citação
Hippocampus. Hoboken: Wiley-liss, v. 18, n. 11, p. 1089-1093, 2008.