The association between the Framingham risk score and sleep: A São Paulo epidemiological sleep study

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dc.contributor.authorCintra, Fátima Dumas [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.authorSantos-Silva, Rogerio [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorDe Paola, Angelo Amato Vincenzo [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:20Z
dc.date.available2016-01-24T14:27:20Z
dc.date.issued2012-06-01
dc.description.abstractBackground: Sleep is an important factor in the maintenance of cardiovascular integrity. It seems that cardiovascular injury and sleep impairment is another chicken or egg puzzle and we hypothesized that the higher the cardiovascular risk factors the higher the sleep impairment. Therefore, the goal of this study is to analyze the sleep profile of a general population based on cardiovascular risk stratification.Methods: This population-based survey used a probabilistic three-stage cluster sample of São Paulo inhabitants to represent the population. A sample size of 1056 volunteers was defined in order to allow for prevalence estimates with 3% precision. From the 1101 selected and interviewed participants, a complete full-night polysomnogram (PSG) was performed in 1042 participants as well as clinical evaluation and blood samples analyses to assess Framingham risk score.Results: Nine hundred four subjects were classified according the Framingham score and were included in the analyses. A total of 91.7% were classified as a low risk, 5.8% in the intermediate, and 2.4% in the high risk groups according to Framingham score. All polisomnographic parameters were different between groups, except those related to REM sleep parameters. AHI were greater in the high risk compared to the intermediate and low risk groups (23.9 +/- 2.8; 17.7 +/- 1.8; 7.2 +/- 0.5, respectively, p < 0.001), as well as a lower total sleep time in minutes (295.3 +/- 16.2; 338.4 +/- 10.2; 347.4 +/- 2.6, respectively, p = 0.01). Sleep efficiency in percentage also exhibits a reduction between groups (67.6 +/- 2.5; 78.4 +/- 1.6; 82.9 +/- 0.4, respectively, p < 0.001). After adjustment for confounder factors age (p < 0.001) and sleep efficiency (p = 0.06) remained strongly associated with high risk population.Conclusion: High Framingham risk score was associated with poor sleep efficiency and aging. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/50525-1
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.format.extent577-582
dc.identifierhttps://dx.doi.org/10.1016/j.sleep.2011.12.016
dc.identifier.citationSleep Medicine. Amsterdam: Elsevier B.V., v. 13, n. 6, p. 577-582, 2012.
dc.identifier.doi10.1016/j.sleep.2011.12.016
dc.identifier.issn1389-9457
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34963
dc.identifier.wosWOS:000306304700005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleepen
dc.subjectCardiovascularen
dc.subjectObstructive sleep apneaen
dc.subjectSleep efficiencyen
dc.subjectFramingham risken
dc.subjectArterial hypertensionen
dc.subjectCholesterolen
dc.titleThe association between the Framingham risk score and sleep: A São Paulo epidemiological sleep studyen
dc.typeinfo:eu-repo/semantics/article
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