Altered Balance of gamma-Aminobutyric Acidergic and Glutamatergic Afferent Inputs in Rostral Ventrolateral Medulla-Projecting Neurons in the Paraventricular Nucleus of the Hypothalamus of Renovascular Hypertensive Rats

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dc.contributor.authorBiancardi, Vinicia Campana
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorStern, Javier Eduardo
dc.contributor.institutionMed Coll Georgia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:23Z
dc.date.available2016-01-24T13:59:23Z
dc.date.issued2010-03-01
dc.description.abstractAn imbalance of excitatory and inhibitory functions has been shown to contribute to numerous pathological disorders. Accumulating evidence supports the idea that a change in hypothalamic gamma-aminobutyric acid (GABA)-ergic inhibitory and glutamatergic excitatory synaptic functions contributes to exacerbated neurohumoral drive in prevalent cardiovascular disorders, including hypertension. However, the precise underlying mechanisms and neuronal substrates are still not fully elucidated in the present study, we combined quantitative immunohistochemistry with neuronal tract tracing to determine whether plastic remodeling of afferent GABAergic and glutamatergic inputs into identified RVLM-projecting neurons of the hypothalamic paraventricular nucleus (PVN-RVLM) contributes to an imbalanced excitatory/inhibitory function in renovascular hypertensive rats (RVH). Our results indicate that both GABAergic and glutamatergic innervation densities increased in oxytocin-positive, PVN-RVLM (OT-PVN-RVLM) neurons in RVH rats. Despite this concomitant increase, time-dependent and compartment-specific differences in the reorganization of these inputs resulted in an altered balance of excitatory/inhibitory inputs in somatic and dendritic compartments. A net predominance of excitatory over inhibitory inputs was found in OT-PVN-RVLM proximal dendrites. Our results indicate that, along with previously described changes in neurotransmitter release probability and postsynaptic receptor function, remodeling of GABAergic and glutamatergic afferent inputs contributes as an underlying mechanism to the altered excitatory/inhibitory balance in the PVN of hypertensive rats. J. Comp. Neurol. 518:567-585, 2010. (C) 2009 Wiley-Liss, Incen
dc.description.affiliationMed Coll Georgia, Dept Physiol, Augusta, GA 30912 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDNational Institutes of Health: R01HL68725
dc.description.sponsorshipIDCAPES: BEX0325/03-1
dc.format.extent567-585
dc.identifierhttp://dx.doi.org/10.1002/cne.22256
dc.identifier.citationJournal of Comparative Neurology. Hoboken: Wiley-liss, v. 518, n. 5, p. 567-585, 2010.
dc.identifier.doi10.1002/cne.22256
dc.identifier.issn0021-9967
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32311
dc.identifier.wosWOS:000273620800001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Comparative Neurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectsynapticen
dc.subjectsympatheticen
dc.subjectplasticityen
dc.subjectbrainstemen
dc.subjectimmunohistochemistryen
dc.subjecthypertensionen
dc.titleAltered Balance of gamma-Aminobutyric Acidergic and Glutamatergic Afferent Inputs in Rostral Ventrolateral Medulla-Projecting Neurons in the Paraventricular Nucleus of the Hypothalamus of Renovascular Hypertensive Ratsen
dc.typeinfo:eu-repo/semantics/article
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