PPG - Patologia

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https://hdl.handle.net/11600/61161

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Navegando PPG - Patologia por Autor "Barata, Mariangela Cristina Crispino [UNIFESP]"

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    Análise da expressão de moléculas de adesão celular nos linfomas de células t cutâneos e em doenças inflamatórias da pele
    (Universidade Federal de São Paulo (UNIFESP), 2016-11-23) Barata, Mariangela Cristina Crispino [UNIFESP]; Silva, Maria Regina Regis Silva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    To investigate possible differences in cell adhesion molecules expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis). Patients and Methods: We selected 33 biopsies from patients with mycosis fungoides and 10 biopsies of patients with inflammatory skin diseases from Departamento de Patologia da Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of ?4?1 integrin, ?E?7 integrin and E-cadherin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting four high power microscopic epidermal fields (400x) and comparing those between the two groups. Results: There was no difference in the expression of integrins ?4?1 and ?E?7 in intraepidermal lymphocytes between cases of MF and inflammatory skin diseases. We observed increased expression of integrin ?E?7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4) and in cases of MF after treatment. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis and intercelular oedema reduced it?s expression in keratinocytes. Conclusion: The increased expression of integrin ?E?7 in advanced stages of MF (T3 and T4) can occur due to increased lymphocyte population or the presence of lymphocytes that also express that integrin, although it may not necessarily be activated. Increased expression of ?E?7 in intraepidermal lymphocytes of posttreatment MF cases may be related to the increase of non-tumoral infiltrating lymphocytes in the epidermis. The expression of E-cadherin in the epidermis in cases of MF outlined Pautrier microabscesses, unlike inflammatory diseases, in which there is swelling, breaking of intercellular bridges and decreased expression of this molecule, showing that tumor lymphocytes may migrate to the epithelium in a less aggressive manner, respecting the structure of keratinocytes.