Navegando por Palavras-chave "80 and over"

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    25(oh)vitamina d como preditor de desfechos e óbito em idosos longevos
    (Universidade Federal de São Paulo (UNIFESP), 2016-10-26) Pontes, Tatiana Elias de [UNIFESP]; Cendoroglo, Maysa Seabra Cendoroglo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    25(OH) Vitamin D as Predictor of Outcomes and Death in Oldest Old One of the greatest cultural achievements of a people in their humanization process is the aging of its population, reflecting the improvement of living conditions. Some factors that contribute to active aging can benefit the raising number of oldest old people. Vitamin D and life style have shown impact on functionality and mortality. That context, this study has aimed to evaluate the relationship between serum levels of 25(OH) Vit D, outdoor activity, poor outcomes and death in independent oldest old. We selected 258 community-dwelling and independent elderly people with 80 years old or more, accompanied the Geriatrics and Gerontology Division, Federal University of São Paulo. We dose serum levels of 25(OH)D and apply a questionnaire on skin type, sun exposure and falls. We evaluated the mortality through the death certificate or register in medical records from April 2010 to March 2016. During the survival analysis, we have used the models of Kaplan-Meier and Cox. Around 70.5% were women between 80 to 89 years old (80.2%), 38.8% had daily sunlight exposure > 15 minutes and 20.1% were chronic fallers. Regarding 25(OH)D, 9.3% had serum levels < 10 ng/mL, while 76.4% between 10-30 ng/mL and 14.3% showed values > 30 ng/mL. During the observational period, 65.9% of the old oldest have stayed independent, and 17.1% have deceased. The analysis of survival time have shown that men (HR=2.7, p=0.003), over 90 years old (HR= 4.12, p < 0.001), with levels of 25(OH)VitD < 10 ng/mL (HR=3.2, p=0.004) and chronic fallers (HR=1.97, p=0.042) have shown a lower survival in comparison to the other oldest old; while women, aged 80-89 years, with a level of 25(OH) VitD > 10ng/mL and not chronic fallers, have characterized the lower risk group. Thus, we have identified that insufficient levels of 25(OH) VitD contribute to increased risk of death in the oldest old.
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    Demência, homocisteína, proteína C reativa, HDL-Colesterol, função renal e Vitamina D em idosos longevos - análise de cluster
    (Universidade Federal de São Paulo (UNIFESP), 2016-09-30) Laks, Renato [UNIFESP]; Cendoroglo, Maysa Seabra [UNIFESP]; http://lattes.cnpq.br/6897068755022692; http://lattes.cnpq.br/4056688080816727; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Identifying the risk factors for dementia is very important in order to avoid the onset of illness. Some risk markers such as homocysteine, 25 (OH) VITD, CRP, HDL-Col and renal function are very prevalent in the elderly, potentially modifiable and can be risk factors for dementia. Objective: To evaluate through cluster analysis the relationship between cognitive function and the risk markers homocysteine, C-reactive protein, renal function, 25-hydroxyvitamin D3 and HDL-cholesterol. Validate formed clusters relating them to the incidence of dementia, stroke and death. Methods: Elderly individuals aged 80 years and older, with no cognitive or functional loss underwent an initial assessment and data applied to cluster analysis by two steps method. The formed clusters were compared with respect to demographic variables, the performance on the clock drawing test, verbal fluency animals, brief cognitive battery, Mini Mental State examination, GDS and serum biochemical markers. To validate the cluster, we evaluated the incidence of dementia, stroke and occurrence of death in the period of 2010 to 2016. Results: At baseline were included 156 elderlies, 69.2% female, mean age 84.8 years. The clustering obtained positive silhouette coefficient (+0.3). The decreasing order of importance of risk markers to the clustering process was BIS_Cr, HDL-Col, homocysteine, CRP, and 25 (OH) VitD. Comparing the initial cognitive tests among the three formed clusters, they differed only on the clock drawing test. During the follow-up to six years 13.5% of all participants developed dementia, 5.1% Stroke and 10.9% died. The incidence of dementia, stroke and deaths in this period was significantly lower in the cluster 2 (p = 0.005), which had intermediate values of homocysteine and creatinine clearance, and the highest CRP, HDL-cholesterol and 25 (OH)VitD. The cluster with lower levels of creatinine clearance, HDL-col and 25 (OH) VITD, higher levels of homocysteine and intermediate levels of CRP, showed higher incidence of dementia, stroke and death. Moreover, the incidence of these outcomes was significantly lower in the cluster 2 (p = 0.005), which had intermediate levels of homocysteine and creatinine clearance, and higher HDL-cholesterol levels, 25-dihydroxyvitamin D3 and CRP. Conclusion: The combination of creatinine clearance greater than 45 mL / min / 1.73m2, HDL-Col greater than 60 mg / dL, 25 (OH)vit D greater than 20 mmol /L