Navegando por Palavras-chave "Airway Inflammation"

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    pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers
    (Faculdade de Medicina / USP, 2013-12-01) Lima, Thamires Marques de; Kazama, Cristiane Mayumi; Koczulla, Andreas Rembert; Hiemstra, Pieter S.; Macchione, Mariangela; Fernandes, Ana Luisa Godoy [UNIFESP]; Santos, Ubiratan de Paula; Bueno-Garcia, Maria Lucia; Zanetta, Dirce Maria; Andre, Carmen Diva Saldiva; Saldiva, Paulo Hilário Nascimento; Nakagawa, Naomi Kondo; Universidade de São Paulo (USP); Philipps University; Leiden University Medical Center; Universidade Federal de São Paulo (UNIFESP); Instituto do Coração
    OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1β and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.
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    Sakuranetin reverses vascular peribronchial and lung parenchyma remodeling in a murine model of chronic allergic pulmonary inflammation
    (Cadernos Saude Publica, 2016) Pedroso Sakoda, Camila Pivari [UNIFESP]; de Toledo, Alessandra Choqueta; Perini, Adenir; Pinheiro, Nathalia Montouro; Hiyane, Meire Ioshie; Grecco, Simone dos Santos [UNIFESP]; Lopes Calvo Tiberio, Iolanda de Fatima; Saraiva Camara, Niels Olsen; Martins, Milton de Arruda; Ghilardi Lago, Joao Henrique [UNIFESP]; Righetti, Renato Fraga; Prado, Carla Maximo [UNIFESP]
    Background and purpose: Asthma is a disease of high prevalence and morbidity that generates high costs in hospitalization and treatment. Although the airway is involved in the physiopathology of asthma, there is also evidence of the importance of vascular and lung parenchyma inflammation and remodeling, which can contribute to the functional pulmonary alterations observed in asthmatic patients. Our aim was to evaluate treatment using sakuranetin, a flavone isolated from the twigs of Baccharis retusa (Asteraceae), on vascular and lung parenchyma alterations in an experimental murine model of asthma. Methods: Male BALB/c mice were subjected to a sensitization protocol with ovalbumin for 30 days and were treated with or without sakuranetin (20 mg/kg/mice) or dexamethasone (5 mg/kg/mice)