Navegando por Palavras-chave "Antimicrobial Cationic Peptides"

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    Síntese, Caracterização E Determinação Do Potencial Antimicrobiano De Nanopartículas Superparamagnéticas De Óxido De Ferro Funcionalizadas Com O Peptídeo Antimicrobiano Ocelatina Pt7 Dissertação
    (Universidade Federal de São Paulo (UNIFESP), 2018-08-30) Oyadomari, William Yoshio Agliardi [UNIFESP]; Daghastanli, Katia Regina Perez [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Recently, Many Studies Have Focused On The Development Of Drug Carriers To Bring A Bioactive Molecule To Target Tissue Using Lower Doses Of The Drug And Thus Reducing Its Toxicity. In This Work We Develop And Characterize Nanoparticles Of Superparamagnetic Iron Oxide (Spion) Bound To Ocelatina Pt7, An Antimicrobial Peptide. The Nanoparticles Were Synthesized Using The Co-Precipitation Method Of Iron (Iii) And Iron (Ii) (2: 1 Mol / Mol) With Nh4oh In The Presence Of Oleic Acid Under A Nitrogen Atmosphere And Under Stirring. The Final Suspension Of Nanoparticles Responded To The Magnetic Field Generated By A Magnet And Was Characterized By Dynamic Light Scattering (Dls), Zeta Potential (Zp), Fourier Transform Infrared Spectroscopy (Ftir), Scanning Electron Microscopy (Sem), Crystallography Of X-Ray And Optical Microscopy. Nanoparticles Not Coated With Oleic Acid Have A Hydrodynamic Diameter Of 1400 Nm, A Zp Of -23 Mv And Coalesce Rapidly. The Coating With Oleic Acid Decreased The Hydrodynamic Diameter Of The Na