Navegando por Palavras-chave "Biópsia de linfonodo sentinela"
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- ItemAcesso aberto (Open Access)99mTC-fitato e 99mTc-dextran 500 na linfocintilografia para biópsia de linfonodo sentinela em ratos(Universidade Federal de São Paulo (UNIFESP), 2004) Paiva, Geruza Rezende [UNIFESP]; Oliveira Filho, Renato Santos de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Embora os procedimentos de biopsia de linfonodo sentinela estejam sendo reproduzidos em diversos centros oncologicos do mundo, existem muitos aspectos a serem melhor definidos para uma padronizacao, como o melhor radiofarmaco a ser utilizado. O objetivo deste estudo foi avaliar qual dos dois radiofarmacos mais frequentemente usados no Brasil, 99mTc-dextran 500 ou 99mTc-fitato define melhor o linfonodo sentinela e migra menos para outros linfonodos apos o linfonodo sentinela Trinta e dois ratos Wistar-EPM1, randomizados em dois grupos foram submetidos a linfocintilografia com 99mTc-dextran 500 ou 99mTc-fitato, e a biopsia dos linfonodos popliteo (sentinela) lombares e inguinais. A radioatividade nos linfonodos, no local da injecao do radiofarmaco, no leito operatorio e a de fundo foram medidas nos grupos e comparadas. O estudo estatistico (teste t de Student, teste de Mann-Whitney, analise de variancia de Friedman e teste de Wilcoxon) comparou os grupos 99mTcdextran 500 e 99mTc-fitato e demonstrou que os dois radiofarmacos migraram do local de injecao ate o linfonodo sentinela e o identificaram como o mais captante de forma semelhante. Demonstrou tambem que o radiofarmaco 99mTc-fitato migrou menos e para menor numero de linfonodos apos o linfonodo sentinela. A radioatividade encontrada no leito operatorio e a radiacao de fundo nao mostraram diferenca estatistica significante. Com estas propriedades pode-se concluir que o radiofarmaco 99mTc-fitato e melhor que o 99mTc-dextran para o procedimento de biopsia de linfonodo sentinela
- ItemAcesso aberto (Open Access)Equipamento brasileiro de detecção gama intra-operatória para biópsia de linfonodo sentinela(Colégio Brasileiro de Cirurgiões, 2010-02-01) Oliveira Filho, Renato Santos de [UNIFESP]; Farah, Andréia Bufoni; Costa, Fábio Eduardo da; Nahas, Fabio Xerfan [UNIFESP]; Oliveira, Daniel Arcuschin de; Oliveira, Renan Gianotto de; Hospital Israelita Albert Einstein; IPEN; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina Anhembi-MorumbiOBJECTIVE: To test the effectiveness of an intra-operative gamma detection Brazilian device (IPEN) on sentinel lymph node biopsy (SLNB) procedures. METHODS: Forty melanoma or breast cancer patients with indication for undergoing SLNB were studied. Lymphoscintigraphy was done 2 to 24 hours prior to surgery. Lymphatic mapping with vital dye and gamma detection were performed intraoperatively. For gamma detection Neoprobe ® 1500 was used followed by IPEN (equipment under test) in the first 20 patients and for the remaining half IPEN was used first to verify its ability to locate the sentinel node (SN). Measurements were taken from the radiopharmaceutical product injection site, from SN (in vivo and ex vivo) and from background. It was recorded if the SN was stained or not and if it was found easily by surgeon. RESULTS: There were 33 (82.5%) breast cancer and 7 (17.5%) melanoma patients. Ages varied from 21 to 68 year-old (median age of 46). Sex distribution was 35 (87.5%) women and 5 (12.5%) men. Sentinel node was found in all but one patient. There was no statistical difference between the reasons ex vivo/ background obtained with the measures of both equipments (p=0, 2583-ns). The SN was easily found by the surgeon with both devices. CONCLUSION: The SLNB was successfully performed using either equipment. It was possible to do SLNB with the Brazilian device developed by IPEN without prejudice for the patient.
- ItemAcesso aberto (Open Access)Experimental model in rat for sentinel node biopsy(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2003-01-01) Oliveira Filho, Renato Santos de [UNIFESP]; Paiva, Geruza Rezende [UNIFESP]; Wagner, Jairo; Nogueira, Solange Amorim; Universidade Federal de São Paulo (UNIFESP); Hospital Israelita Albert Einstein Nuclear Medicine ServiceAlthough sentinel node procedure has been used world wide, there are many aspects to be defined and better standardized. This study address if the experimental model in rats is appropriate for sentinel node biopsy. In this model, the lymph nodes are showed by lymphoscintigraphy, they are dyed by patent blue and identified by intraoperative gamma probe detection. It isn t necessary to use magnification for the procedure. The model demonstrated that sentinel node biopsy in rats is feasible. So, besides allowing researches in this field, the model is useful for training and diffusing this technique.
- ItemAcesso aberto (Open Access)Mitose como fator prognóstico para biópsia de linfonodo sentinela em melanoma fino(Sociedade Brasileira de Dermatologia, 2011-08-01) Oliveira Filho, Renato Santos de [UNIFESP]; Jorge, Mayra Calil; Oliveira, Daniel Arcuschin de; Oliveira, Renato Leão de; Queiroz, Maria do Carmo Assunção; Nahas, Fabio Xerfan [UNIFESP]; Hospital Israelita Albert Einstein; Universidade Estadual Paulista (UNESP); Universidade Anhembi Morumbi; Santa Casa de Misericórdia de Votuporanga; Laboratório LOCUS Laboratório de Anatomia Patológica; Universidade Federal de São Paulo (UNIFESP)23-year-old female patient, with superficial spreading melanoma (SSM) on the back, Breslow 0.35 mm, Clark II, without ulceration and with 2 mitosis/mm². Patient was submitted to margin enlargement and sentinel biopsy of 2 lymph nodes (left armpit). Histopathology revealed micrometastasis in the subcapsular sinus of both. Following the recommendation of the 2009 American Joint Committee on Cancer Melanoma Staging (AJCC), the patient underwent complete axillary lymphadenectomy. No other lymph nodes were metastatic. The clinical application of dermoscopy has enabled more accurate diagnosis of cutaneous melanoma, probably contributing to a greater proportion of thin melanomas at diagnosis. The mitotic rate was included as an important prognostic factor for thin melanomas by the AJCC, suggesting biopsy for these patients