Navegando por Palavras-chave "Carcinoma Squamous Cell"

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    Estudo Do P16Ink4A Em Carcinoma Espinocelular De Orofaringe E Cavidade Oral Para Pesquisa Do Hpv
    (Universidade Federal de São Paulo (UNIFESP), 2017-09-28) Greggio, Barbara [UNIFESP]; Abrahão, Marcio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: To describe the presence of HPV, in its active form, in squamous cell carcinoma of the oropharynx and oral cavity, by the study of the expression of the p16INK4a protein in immunohistochemical panel, and to relate it to smoking and alcoholism. Method: We selected 46 patients with oral cavity or oropharyngeal carcinoma, that were submitted to surgical treatment between 2014 and 2016. Of the 46 patients studied, 37 were male and 9 were female. Thirty-four patients had oral cavity carcinoma and 12 had oropharynx carcinoma. The 46 paraffin-embedded tumors tissues were analyzed in an immunhistochemistry panel for p16INK4a expression to study the presence of HPV infection in those samples. Results: HPV was present in 6 patients by the immunohistochemistry study of p16INK4a, representing 13.04% among the 46 patients. Among all the male patients, HPV was present in 10.81%. Among the female patients, it was present in 22.22%. Of the 34 patients with tumor in the oral cavity, HPV was present in 4. Of the 12 patients with oropharyngeal tumor, HPV was present in 2. Of all 11 non-smoking and non-alcoholic patients, HPV was present in 3. Among the 10 smoking patients , HPV was found in 1 and among the 25 alcoholic and smoking patients, HPV presented positivity in 2. Conclusion: The presence of HPV in squamous cell carcinoma of the oropharynx and oral cavity by the immunohistochemistry study of p16INK4a was 13.04% . Among the oral cavity tumors, this presence of HPV was 11.76% and in oropharyngeal tumors this presence was 16.66%. In the group of non-smokers and non-alcoholic patients, HPV was present in 27.27%. In smokers and alcohol users, it was present in 8% and in smokers, it was present in 10%.