Navegando por Palavras-chave "Cervical neoplasia"

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    Avaliação da expressão imuno-histoquímica do fator de crescimento endotelial vascular (VEGF) e da podoplanina em neoplasias intraepiteliais escamosas cervicais de graus 1, 2 e 3
    (Universidade Federal de São Paulo (UNIFESP), 2016-07-31) Mattos, Patricia Napoli Belfort [UNIFESP]; Speck, Neila Maria de Góis [UNIFESP]; http://lattes.cnpq.br/8169544398769371; http://lattes.cnpq.br/1721457952387087; Universidade Federal de São Paulo (UNIFESP)
    Background: VEGF and podoplanin in invasive lesions of the cervix might beessential to restrict tumor metastatic spread. The research of these markers by immunohistochemistry can assess the immunedetection profile for diagnostic. The aim of the study was to evaluate and correlate the immunoexpression of VEGF and podoplanin in diferents degrees of cervical intraepithelial neoplasia 1, 2 and 3. Patients and Methods: two hundred thirty-four patients with cervical intraepithelial neoplasia 1, 2, 3 and controls were selected and divided em four groups. Clinical data was collected from the patients? charts and the samples from paraffin-embedded to conventional histopathologic method, construction of tissue microarray and immunohistochemical analysis. Results: We evaluated 43 controls samples, 53 samples from CIN 1 group, 60 from CIN 2 and 78 from CIN3, which the ages between 17-62 years old. Comparisons between groups to VEGF immunoexpression we observed difference statistically significant. The occurency of intense VEGF was statistically greater in CIN 2 and CIN 3 groups when compared to CIN 1 and control groups (p<0,001). The intensety of podoplanin immunoexpression between groups showed statistical significance, the negative and focal expression was more present in CIN 3 when compared to CIN 1, CIN 2 and control (p=0.016). In the immunoexpression correlation of the two factors, the podoplanin was equally frequent in different types of VEGF in control, CIN 1 and CIN 2 groups. Patients with CIN 3 presented greater frequency of VEGF moderate to intense among the patients with negative and focal podoplanin expression when compared to diffuse expression. Conclusions: The groups CIN 2 and CIN 3 appears not to present similarity in the occurrence of VEGF intense when compared to CIN 1 and control. Negative and focal podoplanin expression seems to be more present in CIN 3 when compared to other groups. Patients with CIN 3 appears to showed great tendency to moderate and intense VEGF among the patients with negative and focal podoplanin expression when compared to diffuse. .
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    Avaliação do Programa Nacional de Controle do Câncer do Colo do Útero no Estado de Mato Grosso: impacto sobre o perfil da doença
    (Universidade Federal de São Paulo (UNIFESP), 2010-10-28) Nakagawa, Janete Tamami Tomiyoshi [UNIFESP]; Schirmer, Janine [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    In 2002, the State joined the second phase of intensification of the National Program for the Control of Cervical Cancer (PNCCU) as a measure to deal with the high rates of the disease and of death by cervical neoplasia. With the aim of analyzing the main PNCCU results, a two-stage study was carried out. The first phase aimed at presenting the disease profile and the coverage of the screening exam by the PNCCU in the State. The aims of the second phase were to analyze the clinical follow-up of the population that was screened, analyze the different evolutionary characteristics of the disease associated to socio-demographic and clinic factors, as well as analyze the factors associated to death risk and the stratified survival rate by the socio-demographic and clinical variables of women that presented invasive carcinoma. In the first part, the cross-sectional study was used and a cohort study was used in the second phase. The period of study was from 2002 to 2007 and comprised all the municipalities of the State of Mato Grosso. The population studied in the first phase of the study was all the women who had undergone the screening test in 2002. The population used in the second phase of the study was a representative random sample of those that presented cytological alterations in the first phase of the study, a total of 323 women. The source of data used was the official health information system, among them the SISCOLO, SIM, APAC, and also the official data of the State Health Department/MT (SES/MT), data available in the INCA and DATASUS sites and medical records. For the statistical analysis of the data, descriptive and inferential techniques were used. In the descriptive part, tables, graphics and position and dispersion measures were used. In order to evaluate the risk of being sick due to invasive cervical carcinoma, the univariate and multivariate logistic regression analysis was used. The Kaplan-Meier estimator was used to analyze the survival rate and to analyze the prognostic factors, the Cox proportional hazards model was used. Among the main results it is highlighted that in 2002, Mato Grosso presented high incidence rates, above the national average. The data of the clinical follow up showed the different clinical outcomes, among the 323 women, 18 (6,2%) died having as the basic cause of death the cervical cancer. The risk of the disease developing into the invasive carcinoma was analyzed according to the socio-demographic and clinical variables, and the variables: age group, marital status, smoking history, menopause and municipality were those that presented a strong association with the disease in the invasive phase. However, in the survival analysis, the global survival rate in 60 months, estimated by the Kaplan-Meier method, was of 66,7%. In the final Cox proportional hazards model, the variables with higher death risk was the advanced stage of the disease and the race/color. These data lead to a conclusion that the disease in the State of Mato Grosso has a very large social determination, considering the difficulties in the access to the health services by the population affected by racial, socio-economic conditions that arrive in the health services with the disease in an advanced stage, when the survival probability is very small. The conclusion is that for the effective fight against the disease governmental policies such as the PNCCU are necessary, and that the universality of the assistance be guaranteed, mainly to the socially disadvantaged population.