Navegando por Palavras-chave "Cervix"
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- ItemAcesso aberto (Open Access)Angiogênese na Neoplasia Escamosa do Colo Uterino: Comparação entre dois Marcadores de Células Endoteliais(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2001-06-01) Calux, Nilciza Maria de Carvalho Tavares [UNIFESP]; Focchi, José [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]; Stávale, João Norberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: to compare the efficiency of anti-factor VIII and anti-CD34 antibodies as vascular makers in cervical cancer, in cervical intraepithelial neoplasia and in normal cervix. Methods: using an immunohistochemical method, factor VIII-related antigen and leukocyte antigen CD34, we performed microvascular counts in 18 squamous cell carcinomas, in 15 cervical high-grade intraepithelial neoplasia, in 15 low-grade intraepithelial lesions and in 10 normal cervices. Using light microscopy we counted microvessels per 400X field in the most active areas of neovascularization with higher microvessel density in each case. Results: the average of microvessels stained with anti-CD34 in invasive carcinoma, high-grade intraepithelial lesions, low-grade intraepithelial lesions and in the normal cervices was 154, 134, 112 and 93, respectively. When we used anti-factor VIII the average was 56, 44, 33 and 30 vessels, following the same order. High-grade intraepithelial lesions and invasive carcinomas showed greater means number of vessels than normal tissue. Conclusions: the use of anti-CD34 allowed the detection of a greater number of vessels when compared to anti-factor VIII. However, we could observe that anti-factor VIII staining was able to significantly discriminate high-grade from low-grade lesions.
- ItemAcesso aberto (Open Access)Avaliação do Grau e da Extensão das Alterações Térmicas Produzidas pela Cirurgia de Alta Freqüência no Colo Uterino(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2001-02-01) Taha, Nabiha Saadi Abrahão [UNIFESP]; Focchi, José [UNIFESP]; Ribalta, Julisa Chamorro Lascalas [UNIFESP]; Stávale, João Norberto [UNIFESP]; Dores, Gerson Botacini das [UNIFESP]; Lima, Geraldo Rodrigues De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: to evaluate the incidence of thermal damage to the specimens excised through large loop excision of the transformation zone (LLETZ) and to determine qualitatively and quantitatively the thermal injury to the ectocervical and endocervical epithelia as well as the influence of the menstrual phase on such process. Methods: we performed a prospective study of 100 patients with high-grade squamous intraepithelial lesions (HGSIL). Thermal damage was subdivided into three grades according to Messing et al¹. Results: thermal injury occurred in all the cases, however, through statistical analysis we found that in 91% of the cases it was insignificant, thus leading to a precise histological evaluation, hence to measure the thermal injury was unnecessary. The grade and extent of thermal damage in excised specimens using LLETZ had no relation to the menstrual phase. The extension of thermal tissue alteration in the endocervical epithelia was 271,6 mu while the extension in ectocervical epithelia was 254,8 mu, showing that the extension of thermal damage is significantly higher in endocervical epithelia. Of the one hundred patients, 80 were in menacme and 20 in menopause correlating the grade and extension of thermal damage with the menstrual state. Conclusion: there was no significant difference in both qualitative and quantitative evaluations. There is no need to measure the thermal damage.
- ItemSomente MetadadadosDepth of glandular crypts and its involvement in squamous intraepithelial cervical neoplasia submitted to large loop excision of transformation zone (LLETZ)(I R O G Canada, Inc, 2013-01-01) Okazaki, C. [UNIFESP]; Focchi, Gustavo Rubino de Azevedo [UNIFESP]; Taha, Nabiha Saadi Abrahão [UNIFESP]; Ahmeida, P. Q. [UNIFESP]; Schimidt, M. A. [UNIFESP]; Speck, Neila Maria de Góis [UNIFESP]; Ribalta, Julisa Chamorro Lascasas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: The authors aimed to confirm the depth of six mm in order to achieve an optimal eradication of the lesion. Materials and Methods: This is a retrospective observational study of 94 cervical surgical pieces from women aged 17 to 22 years with a cytocolpo-histopathological diagnosis of high-grade squamous cervical intraepithelial neoplasia (CIN II and/or CIN III) submitted to large loop excision of transformation zone (LLETZ). The glandular crypts and margins, both exposed or not to CIN, were assessed. The compromise and the maximum depth of the glandular crypts were noticed. Results: After LLETZ, 23 (24.47%) cases presented a neoplasic impairment of endocervical margin and ten (10.64%) of the ectocervical margin. The largest noticed crypt measured 4.500 mm and the shortest 0.100 mm, with an average of 2.148 mm.-Conclusions: Squamous CIN more frequently show the exposure of surgical margins to LLETZ. The deeper location of glandular crypts in the cases studied was 4.500 mm, while the largest neoplastic extension was 3.000 mm The therapeutic method depends on this knowledge.
- ItemSomente MetadadadosMAGNETIC RESONANCE IMAGING VS. TRANSVAGINAL ULTRASOUND for CERVICAL LENGTH ASSESSMENT in the SECOND HALF of PREGNANCY(Elsevier B.V., 2010-04-01) Brandão, Rosieny Souza [UNIFESP]; Pires, Claudio Rodrigues [UNIFESP]; Souza, Eduardo de [UNIFESP]; Avanza, Leonardo Luiz [UNIFESP]; Mattar, Rosiane [UNIFESP]; Araujo Junior, Edward [UNIFESP]; Marcondes, Luciano [UNIFESP]; Nardozza, Machado [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The purpose of this cross-sectional study involving 42 women between 20 and 39 weeks gestation was to compare transvaginal ultrasound (TVUS) vs. magnetic resonance imaging (MRI) in the assessment of cervical length measurement during the second half of pregnancy and to evaluate the reproducibility of cervical measurements obtained through MRI. Cervical length was measured through TVUS by a single examiner. On the same day, all women also had MRI and cervical length was assessed by two independent blinded observers. There were no significant differences in the mean cervical length obtained through TVUS and MRI (paired t-test, p = 0.191). the Bland-Altman test indicated concordance between measurements obtained through methods as well as good intra- and interobserver reproducibility for MRI measurements. Intraclass correlation coefficient was 0.990 (95% confidence interval [CI]: 0.982 to 0.995; p < 0.001) for measurements performed using MRI by two different observers and 0.995 (95% CI: 0.991 to 0.997; p < 0.001) for measurements performed using the same method by a single operator. Cervical length measured through TVUS and MRI does not differ significantly. There is a good reproducibility of cervical measurements obtained through MRI. (E-mail: crpires@ uol.com.br) (C) 2010 World Federation for Ultrasound in Medicine & Biology.
- ItemAcesso aberto (Open Access)Relação entre o uso de contraceptivos e a citologia oncótica cérvico-vaginal(Universidade Federal de São Paulo, 2022-01-27) Lima, Grasiele de Cássia Baião [UNIFESP]; Di Bella, Zsuzsanna IIona Katalin de Jármy [UNIFESP]; Speck, Neila Maria de Gois [UNIFESP]; http://lattes.cnpq.br/8169544398769371; http://lattes.cnpq.br/7368804318575164; http://lattes.cnpq.br/8505790768535994Objetivo: O estudo tem como objetivo analisar o uso de contraceptivos e os resultados de citologia cérvico-vaginal em mulheres atendidas em Ambulatórios de Planejamento Familiar (PF) e Patologia do Trato Genital Inferior (PTGI) do Departamento de Ginecologia da Escola Paulista de Medicina -UNIFESP, em 2020. Método: Trata-se de um estudo observacional, comparativo e transversal. A amostra foi formada por 177 mulheres no menacme dos 25 aos 50 anos. Para a coleta levantou-se dados demográficos, antecedentes ginecológicos, sexuais e antecedentes obstétricos. As análises foram realizadas no Excel e no software estatístico com os testes de Mann Whitney, T de Student, análise da regressão logística, teste Qui-Quadrado, exato de Fisher e teste da razão de verossimilhança. Resultados: 95 (53,7%) das pacientes foram atendidas no PF e 82 (46,3%) na PTGI. Os métodos contraceptivos hormonais mais utilizados na PTGI foram os combinados (28,1%) e os progestagênios isolados (14,7%) não incluindo o DIU hormonal e no PF, 16,9% utilizavam métodos combinados e 10,5% progestagênios isolados sem incluir o DIU hormonal. Nas citologias oncóticas, ficou evidente que o grupo do PF apresentou percentual menor de alterações do que as pacientes da PTGI, sendo 92,7% do PTGI e 3,2% do PF. O uso de nenhum método contraceptivo, seguido pelo uso de métodos combinados e de progestagênio isolado e do uso de métodos não hormonais foram associados a maior chance de alterações na CO comparado a usuária de DIU de cobre. Conclusão: Assim, o uso de DIU de cobre, a ocorrência de parto cesárea e de abortamentos mostraram serem fatores protetores para citologia cérvico-vaginal alterada, enquanto ser solteira ou divorciada, ter escolaridade baixa e fazer uso irregular de método contraceptivo são considerados fatores de risco.