Navegando por Palavras-chave "Chia Flour"

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    Efeito da ingestão da farinha da semente de chia (Salvia Hispanica L) no cólon intestinal de camundongos obesos
    (Universidade Federal de São Paulo (UNIFESP), 2017-08-31) Miranda, Danielle Araujo de [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Obesity has been considered a public health issue worldwide, in which the main causes are the intake of a hypercaloric diet as well as sedentarism. It is often associated with with several other diseases such as insulin resistance, type 2 diabetes mellitus, non-alcoholic fatty liver disease and cardiovascular diseases. Increased intestinal permeability may favor endotoxemia generated by lipopolysaccharide, a substance present in the cell membrane of Gram-negative bacteria, and consequently an increase in systemic inflammation and metabolic diseases. On the other hand, the consumption of a healthy diet can help in the prevention and treatment of the metabolic syndrome. In this way, the chia seed (Salvia hispánica L.), rich in polyunsaturated fatty acids, may present an anti-inflammatory role. In addition, chia is rich in antioxidants like caffeic acid and gallic acid, fiber and minerals. However, there are few studies involving chia seed, inflammatory mechanisms and intestinal permeability. Thus, the objective of this study was to analyze the effects of chia administration on intestinal permeability in obese mice. Swiss mice were treated with a hyperlipidic diet associated or not with supplementation with 3% chia flour for 16 weeks. We analyzed the metabolic profile, such as serum triglyceride, cholesterol, HDL-cholesterol, glucose tolerance test, antioxidant enzyme activity and the quantification of inflammatory pathways and tight junctions of the intestinal colon. The results show that a hyperlipidic diet intake promoted an increase of the mesenteric white adipose tissue weight and in glucose intolerance, and a decrease in the activity of hepatic catalase and the amount of occludin in the intestinal colon. Supplementation with 3% of chia flour was not efficient in decreasing the deleterious effects of lipid-rich dietary intake. In addition, supplementation with chia worsened glucose intolerance in animals receiving a hyperlipidic diet whereas in animals receiving a control diet, supplementation decreased the amount of occludin in the intestinal colon. In conclusion, the beneficial effects of chia seems to be dependent of the quantity how It is offered, since our data are conflicting with those of the literature, however, it is important to note that most of the studies, unlike our protocol, used chia in the form of seed or oil, and not the flour.
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    Efeito Da Suplementação Alimentar Com Farinha De Chia (Salvia Hispanica L) Noprocesso Inflamatórioe Desenvolvimento Tumoral Em Ratos Wistar Inoculados Com Tumor De Walker 256
    (Universidade Federal de São Paulo (UNIFESP), 2017-08-31) Carnier, Marcela [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Chia (Salvia hispanica L.) seeds contain large amounts of n-3 α-linolenic acid (ALA) and have been associated with many health benefits. The objective of the present study was to evaluate the effect of the diet throughout life, supplemented with chia flour in the development of cancer cachexia and inflammatory tissue response. Wistar rats at 30 days of age were treated with control diet or diet supplemented with chia flour for 8 weeks. After this period, a portion of the animals were inoculated with Walker 256 tumor cells. On the fourteenth day after tumor inoculation, the animals were euthanized and deposits of white adipose tissue, liver, gastrocnemius muscle and tumor were removed. Tumor weight increased and IL-10 content decreased in the group supplemented with chia flour. The presence of the tumor did not modify the cytokine content in the adipose tissues retroperitoneal and epididimal and gastrocnemius muscle. However, it decreased the protein content of IL-1β and TNF-α in the liver and IL-6R and IL-10R in mesenteric adipose tissue. In conclusion, our results demonstrated that supplementation with chia flour did not prevent the effects resulting from inoculation and tumor development in the Walker 256 model.