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    Toxicidade do extrato de grapefruit in vitro e em ratos
    (Universidade Federal de São Paulo (UNIFESP), 2009) Guedes, Carolina Cardoso [UNIFESP]
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    Toxicidade do extrato de grapefruit in vitro e em ratos
    (Universidade Federal de São Paulo (UNIFESP), 2010-02-27) Guedes, Carolina Cardoso [UNIFESP]; Amâncio, Olga Maria Silvério [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Toxicity of the grapefruit extract (GSE) was analyzed in vitro and in rats. The experimental groups were 0.1% GSE, 0.15% GSE, 0.2% GSE, 0.5% GSE, 0.12% chlorhexidine and control (in vitro study) or sham (rats study). The in vitro test was performed on fibroblast cultures (NIH-3T3) in order to assess cell survival at 1, 3, 5 and 7 days. In the test performed on rats, polyethylene tubes containing the substances were implanted in connective tissue; histological analysis of tissue samples was performed at 1, 7, 15, 30 and 60 days. Both the GSE and chlorhexidine proved cytotoxic, with a greater concentration leading to greater toxicity for fibroblasts. In the connective tissue, GSE caused severe inflammation on the first day at all concentrations. Over time, the inflammation subsided until reaching values similar to the sham group. At the concentrations studied, GSE exhibits toxicity for cells and connective tissue. Further studies are needed to assess the harm this product may cause to human tissue and determine a safe dosage for its use as well as whether a lower concentration still has the desired antimicrobial potential to which it is attributed.