Navegando por Palavras-chave "Common variable immunodeficiency"
Agora exibindo 1 - 3 de 3
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Avaliação das concentrações de vitamina D em pacientes com imunodeficiência comum variável e ataxia-telangiectasia(Universidade Federal de São Paulo (UNIFESP), 2018-05-25) Cruz, Julia Rosental de Souza [UNIFESP]; Sarni, Roseli Oselka Saccardo [UNIFESP]; http://lattes.cnpq.br/1760819469047929; http://lattes.cnpq.br/8769460841656743; Universidade Federal de São Paulo (UNIFESP)Introduction: 1.25 hydroxyvitamin D plays many roles in the body, including the immune system modulation. The Primary Immunodeficiencies (PID) are a group of diseases which affect B and T cells, compromising the humoral and adaptive immunity. Objectives: To assess vitamin D status in AT and CVID patients and, to correlate vitamin D status to: body composition, inflammatory markers and markers of bone metabolism. Methods: Crosssectional, observational and controlled study, involving 15 CVID patients, nine AT patients and 24 healthy controls, paired by sex and age. Were assessed: 25(OH) D – Hydroxyvitamin D, lipid profile, markers of liver function, Creactive protein, parathyroid hormone, alkaline phosphatase, interleukin 6, insulin, phosphorus, calcium, and blood sugar levels. Anthropometric evaluation was also performed. Results: Mean age of 26.0 years. Vitamin D deficiency was found in four AT patients (44%) and two CVID patients (13%). 60% of the CVID patients were overweight. Six (66,7%) AT patients were underweight. A negative correlation between vitamin D and fat mass was found in CVID patients (ρ = 0.5580 e p = 0.306) and a negative correlation between Body Mass Index and vitamin D in AT (ρ = 0,6788 e p = 0,0444). Conclusion: Vitamin D deficiency was found only in the patients group. No correlation with blood markers was found. It was found a negative correlation between vitamin D and body composition.
- ItemRestritoAvaliação do estado nutricional relativo a retinol, beta caroteno e zinco em pacientes com imunodeficiência comum variável(Universidade Federal de São Paulo (UNIFESP), 2010-08-25) Santos-Valente, Elisangela Calheiro dos [UNIFESP]; Costa-Carvalho, Beatriz Tavares [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: Common Variable Immunodeficiency (CVI) patients presenting diarrhea and weight loss probably have impaired nutrient ingestion and absorption. Objectives: To compare vitamin A and zinc levels in CVI patients and healthy controls and also compare those levels with gastrointestinal (GI) symptoms and bacterial translocation. Methods: CVI patients from the Immunology outpatients clinic from the Federal University of Sao Paulo and age and gender-matched healthy controls underwent nutritional and laboratorial evaluation with CBC, C reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta carotene, serum and erythrocyte zinc. Results: Seventeen patients (mean age 28.54y) and 17 controls were included in the study. Retinol levels were lower in patients compared to controls: 1.99 ( }0.67) and 2.72ƒÊmol/L ( }0.96), respectively, p=0.014. Likewise, serum zinc levels were 50.0 (50-100) in the patients and 100.0ƒÊg/dL (50-150) in the control group, (p=0.020). For erythrocyte zinc the levels were 37.32 ( }10.51) for patients and 44.91ƒÊgZn/gHb ( }7.67) for controls, p=0.045. CRP levels were higher among patients: 4.99 (0.15-34.51), compared to controls: 0.55mg/L (0.17-6.06), p=0.004. There was no difference in the translocation marker levels between the groups. A tendency of lower retinol was seem in those patients with severe GI symptoms compared with those with mild/absent symptoms and health controls. Conclusions: CVI patients presented significant lower retinol and zinc levels and higher CRP levels than the healthy controls with no evidence of bacterial translocation. Nonetheless, those patients with severe GI symptoms tend to have lower retinol levels than the other patients.
- ItemSomente MetadadadosPulmonary complications in patients with antibody deficiency(Elsevier B.V., 2011-05-01) Costa-Carvalho, Beatriz T. [UNIFESP]; Wandalsen, Gustavo F. [UNIFESP]; Pulici, Guilherme [UNIFESP]; Aranda, Carolina Sanchez [UNIFESP]; Sole, Dirceu [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: the aim of this study was to evaluate pulmonary complications in patients with primary antibody deficiency (X-linked agammaglobulinaemia [XLA] and common variable immunodeficiency [CVID]).Methods: Thirty patients over six years of age regularly followed in a reference out-patient clinic on primary immunodeficiency were studied. All of them have been treated with intravenous immunoglobulin (IVIG) replacement therapy. Pulmonary complications were evaluated analysing clinical data (medical records review), lung function test (spirometry) and pulmonary imaging (chest computed tomography [CCT]).Results: Patients with normal CCT (N=14) and those with abnormal CCT (N=16) have shown no differences regarding the age at onset of symptoms, age of diagnosis, and duration of IVIG treatment. the mean number of pneumonia episodes before IVIG replacement was significantly higher among patients with abnormal CCT (4 vs 7 episodes, p=0.008). CCT abnormalities observed in 16 patients were: bronchiectasis (12/16); peribronchial thickening (3/16); air trapping (5/16); lung volume reduction (4/16); atelectasis (2/16), follicular bronchiolitis and ground-glass abnormality (2/16) and parenchyma nodule (1/16). Lung function tests showed ventilatory disturbance in 18/30: obstructive pattern in 38.8%, restrictive pattern in 44.4%, and mix pattern in 16.7%. There were no significant differences in lung function between those with and without CCT abnormalities. Negative significant correlations were observed between lung function and number of episodes of pneumonia. Chronic persistent cough was associated with a reduction in lung function.Conclusions: Pulmonary complications are not rare in patients with antibody deficiencies and they must be monitored. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.