Navegando por Palavras-chave "Connective Tissue"
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- ItemSomente MetadadadosArrangement of collagen fibers in the wall of the main gastrocnemius venous trunk in humans(Elsevier B.V., 2011-01-01) Aragao, Jose Aderval; Reis, Francisco Prado; Costa Baptista Silva, Jose Carlos [UNIFESP]; Miranda, Fausto [UNIFESP]; Universidade Federal de Sergipe (UFS); Tiradentes Univ UNIT; Universidade Federal de São Paulo (UNIFESP)The main gastrocnemius trunk (MGT) drains all of the blood from the network formed by the gastrocnemius veins that emerge from the gastrocnemius muscle. Twenty MGTs were used (nine medial and eleven lateral), from male human cadavers of mean age 31.42 +/- 10.93 years, fixed in 10% formalin solution. the aim of this study was to analyze the arrangement of the bundles of collagen fibers in the wall of the MGT. Sections were stained using Masson's trichrome and picrosirius red solutions and were examined under a polarizing microscope. the bundles of collagen fibers in the wall of the MGT were seen to be arranged in a continuous three-dimensional network, in which bundles crossing in two fundamentally opposite directions formed meshes that, along with the bundles themselves, decreased in size from the tunica adventitia to the tunica intima. These findings may contribute towards understanding the state of functional adaptation of the MGT to responses of dilatation, distensibility and increased venous pressure, in normal and pathological situations. (C) 2010 Elsevier GmbH. All rights reserved.
- ItemAcesso aberto (Open Access)Avaliação da concentração das fibras do tecido conjuntivo quando da associação de poliglactina 910 e silicone: estudo experimental em ratos(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 1997-09-01) Vivi, Ayder Anselmo Gomes [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Oliani, Sonia Maria [UNIFESP]; Gomes, Paulo de Oliveira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual Paulista (UNESP)It is an important area of investigation the choice of an adequate substance for the fixation of silicon prosthesis without generating a lot of fibrotic tissue reaction. We have studied the tissue reaction after the implantation of silicon prosthesis with polyglactin 910 threads. Silicon grids measuring 1,5 x 1,5cm and thickness of 0,7mm were implanted under the subcutaneous tissue of rats. The animals were studied 30, 60 and 90 days after implantation. Then they were sacrificed. The grids and the adjacent tissue were excised. The time did not interfere with the number of colagen fibers in sub-groups. Quantity of colagen fibers were not different amoung the sub-groups of 30, 60 and 90 days. With or without poliglactin 910. In the group of pure silicon grids we have found a significant difference among the reticular fibers. The great number was observed in the 30 and 60 days groups if compared with the group of 90 days. The polyglactin 910 with the silicon grid not change the amount of connective tissue fibers in the grid¢s fenestrations.
- ItemSomente MetadadadosCaracterização da especificidade antinuclear e de fator reumatóide dos anticorpos constituintes dos imunecomplexos circulantes nas doencas difusas do tecido conectivo(Universidade Federal de São Paulo (UNIFESP), 1991) Trevisani, Virginia Fernandes Moça [UNIFESP]; Gabriel Júnior, Alexandre [UNIFESP]
- ItemSomente MetadadadosCyclooxygenase-2 expression in skeletal muscle of knockout mice suffering Duchenne muscular dystrophy(Springer, 2013-05-01) Flavia, De Oliveira [UNIFESP]; Quintana, Hananiah Tardivo [UNIFESP]; Bortolin, Jeferson Andre [UNIFESP]; Gomes, Odair Alfredo; Liberti, Edson Aparecido; Ribeiro, Daniel Araki [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Ribeirao Preto; Universidade de São Paulo (USP)The purpose of the present study was to investigate the role of cyclooxygenase-2 (COX-2) expression in fibrotic lesion in mdx mice. A total of six male C57BL/10 mice and six C57BL/10-DMD/mdx were distributed into two groups: control and animals with Duchenne muscular dystrophy (DMD). the medial part of gastrocnemius muscle was evaluated being the specimens stained with hematoxylin and eosin (H&E) and Sirius Red under normal and polarized light to differentiate type I (red and yellow) and III (green) collagen. COX-2 expression was assessed by immunohistochemistry. the results revealed histopathological changes in C57BL/10-DMD/mdx as depicted by regenerating fibers. Sirius Red stain showed a substantial increase in the amount of type I collagen of mdx mice. DMD induced a strong COX-2 immunoexpression in intercellular space. Taken together, our results are consistent with the notion that necrotic and fibrotic lesions are able to increase COX-2 expression in DMD.
- ItemSomente MetadadadosMorphological changes in distant muscle fibers following thermal injury in Wistar rats(Acta Cirurgica Brasileira, 2010-11-01) De Oliveira, Flavia [UNIFESP]; Bevilacqua, Luci Rezende; Anaruma, Carlos Alberto; Boldrini, Silvia de Campos; Liberti, Edson Aparecido; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Purpose: Thermal injury causes catabolic processes as the body attempts to repair the damaged area. This study evaluated the effects of a scald injury on the morphology of muscle fibers belonging to a muscle distant from the lesion. Methods: Thirty Wistar rats were divided into control (C) and scalded (S) groups. Group S was scalded over 45% of the body surface, standardized by body weight. Rats in both groups were euthanized at four, seven and 14 days following the injury. The middle portions of the medial gastrocnemius muscles were sectioned, stained with hematoxylin and eosin and Picrosirius, and submitted to histological analysis. Results: Control group sections exhibited equidistantly distributed polygonal muscle fibers with peripheral nuclei, characteristic of normal muscle. The injured group sections did not consistently show these characteristics; many fibers in these sections exhibited a rounded contour, variable stain intensities, and greater interfiber distances. A substantially increased amount of connective tissue was also observed on the injured group sections. Conclusion: This experimental model found a morphological change in muscle distant from the site of thermal injury covering 45% of the body surface.