Navegando por Palavras-chave "Craniofacial development"

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    Biometria e assimetria do palato ósseo humano em diferentes grupos etários
    (Universidade Federal de São Paulo (UNIFESP), 2006-01-01) Moreira, Rafael Saviolo [UNIFESP]; Smith, Ricardo Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The purpose of this study was to evaluate hard palate asymmetry during development. The palates of 248 dry skulls were photographed and the digital images were processed with software. The skulls were divided in 7 groups: fetuses, newborns, infants, children, adolescents, adults and aged. Linear measures were obtained from great palatine foramen (GPF) to incisive fossa (INC) and to posterior nasal spine (PNS). Angular measures were obtained from the former landmarks plus the point on sutures intersection between maxillary and palatine bones (SR). Asymmetry was evaluated intra and inter-groups. All skulls showed some degree of right-left asymmetry in the hard palate. Regardless of hard palate asymmetry, none of the right-left side differences was statistically significant. An asymmetry index was used for inter-groups assessment. From fetuses up to aged group, none of the asymmetry index means were statistically different. The posterior part of palate (PNS x GPF) measures were more asymmetric than the anterior part (INC x GPF), showing respectively 4.6% and 2.8% of mean asymmetry index. Angular measures showed a more symmetric behavior than the linear ones. Hard palate asymmetry occurs even in the absence of masticatory function,showing that this feature begins early in fetal life and persists through development.
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    Differential Shh, Bmp and Wnt gene expressions during craniofacial development in mice
    (Elsevier B.V., 2010-01-01) Silva Paiva, Katiucia Batista; Silva-Valenzuela, Maria das Gracas; Gomes Massironi, Silvia Maria; Ko, Gui Mi [UNIFESP]; Siqueira, Filipe Modolo; Nunes, Fabio Daumas; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Santa Catarina (UFSC)
    In this study, Bmp-4, Wnt-5a and Shh gene expressions were compared during early craniofacial development in mice by comparative non-isotopic in situ hybridization. Wild-type C57BL/6J mice were studied at various stages of embryonic development (from 8.5- to 13.5-day-old embryos - E8.5-13.5). During early odontogenesis, transcripts for Bmp-4, Shh and Wnt-5a were co-localised at the tooth initiation stage. At E8.5, Shh mRNA expression was restricted to diencephalon and pharyngeal endoderm. Before maxillae and mandible ossification, Bmp-4 and Wnt-5a signals were detected in the mesenchymal cells and around Meckel's cartilage. During palatogenesis, Shh was expressed only in the epithelium and Wnt-5a only in the mesenchyme of the elevating palatal shelves. During tongue development, Shh expression was found in mesenchyme, probably contributing to tongue miogenesis, while Wnt-5a signal was in the epithelium, possibly during placode development and papillae formation. Taken together, these findings suggest that Bmp-4, Shh and Wnt-5a gene expressions may act together on the epithelial mesenchymal interactions occurring in several aspects of the early mouse craniofacial development, such as odontogenesis, neuronal development, maxillae and mandible ossification, palatogenesis and tongue formation. (C) 2009 Elsevier GmbH. All rights reserved.
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    Palatal asymmetry during development: Am anatomical study
    (Wiley-Blackwell, 2008-07-01) Moreira, Rafael Saviolo [UNIFESP]; Sgrott, Emerson Alexandre [UNIFESP]; Stuker, Henri; Alonso, Luis Garcia [UNIFESP]; Smith, Ricardo Luiz [UNIFESP]; Univ Vale Itajai; Universidade Federal de São Paulo (UNIFESP)
    The purpose of this study was to evaluate hard palate asymmetry during development. the palates of 248 dry skulls were photographed and evaluated digitally. the skulls were divided into seven groups: fetus, newborn, infant, child, adolescent, adult, and aged. Linear measures were obtained from great palatine foramen (GPF) to incisive fossa (INC) and to posterior nasal spine (PNS). Angular measures were obtained from the former landmarks plus the point on sutures intersection between maxillary and palatine bones. Asymmetry was evaluated intra and intergroups. All skulls showed some degree of right-left asymmetry in the hard palate. Regardless of hard palate asymmetry, none of the right-left side differences was statistically significant. for the intergroups assessment, none of the asymmetry index means were statistically different. the posterior part of palate (PNS x GPF) measures was more asymmetric than the anterior part (INC x GPF), showing, respectively, 4.6% and 2.8% of mean asymmetry index. Angular measures showed a more symmetric behavior than the linear ones. Hard palate asymmetry occurs even in the absence of masticatory function, showing that this feature begins early in fetal life and persists through development.