Navegando por Palavras-chave "Defeitos congênitos"

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    Defeitos congênitos e exposição a agrotóxicos no Vale do São Francisco
    (Universidade Federal de São Paulo (UNIFESP), 2010-10-27) Silva, Silvio Romero Gonçalves e [UNIFESP]; Martins, Jose Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: To evaluate associations between genitor exposure to pesticides and births with congenital defects in the São Francisco Valley, as well as the demographic profile and the defects found. Methods: In this case-control study, each case (newborns with congenital defects) had two controls (healthy newborns). The subjects were born at the São Francisco Valley, in 2009. The sample consisted of 42 cases and 84 controls. Data were gathered using a structured questionnaire adapted from Latin American Collaborative Study of Congenital Malformations (ECLAMC), with the addition of questions relating to exposure to pesticides; and from analysis on the medical files and contact with the hospital’s pediatricians. X2 test was performed with a significance level of 5% to identify the variables with the greatest differences between case and control groups. Odds ratios (ORs) for the sample were then calculated, along with ORs from logistic regression analysis; and finally, multivariate logistic regression analysis was performed. Results: Newborns with congenital defects were more associated with genitor exposure to pesticides, in comparison with healthy newborns, but without statistical significance. Greater risk was observed when all types of exposure were considered (adjusted OR: 1.33; 95% CI = 0.45- 3.91). The sociodemographic variables with significant differences between the groups were: low schooling level, low weight, prematurity, young genitors, chronic diseases and physical factors. Multiple malformations and defects of the musculoskeletal and nervous systems were more frequently found. Conclusions: The present study showed association between exposure to pesticides and occurrences of congenital defects. However, without statistical significance.
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    Estudo epidemiológico dos defeitos congênitos registrados no campo 34 da declaração de nascido vivo no município de São Paulo e o estabelecimento de um sistema informatizado de referência e contra-referência
    (Universidade Federal de São Paulo (UNIFESP), 2009-08-26) Nicola, Pablo Domingos Rodrigues de [UNIFESP]; Perez, Ana Beatriz Alvarez [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: The aim of this work was to improve registration of field 34 in born-alive reports of four maternity hospitals in the municipality of São Paulo throughout the year of 2008. Methods: The Born-Alive Information System database of the Municipal Health Secretariat of São Paulo was used in order to accompany the evolution of birth defect registrations. An electronic web-based medical record was used to send dubious cases to a well-established medical genetics center. The electronic medical record contained anamnesis, physical exam, and photos of the newborn. Four maternity hospitals were assessed, with a total sample of 10 000 births in the year; and these hospitals did not have a geneticist amongst the staff. Results: The records of birth defects in São Paulo were: 0.42% in 2001, 0.50% in 2002, 0.53% in 2003, 0.63% in 2004, 0.69% in 2005, 0.73% in 2006, 0.85% in 2007, and 0.91% in 2008. The records of birth defects in the four maternities were: 0.22% in 2001, 0.76% in 2002, 0.92% in 2003, 0.92% in 2004, 1.12% in 2005, 1.27% in 2006, 1.34% in 2007, and 2.02% in 2008. São Paulo registered 0.07 Down syndrome cases per 1000 births in 2008, while the four maternity hospitals registered 0.08 Down syndrome cases per 1000 births in the same year. Conclusions: According to the Born-Alive Information System database, there was a raise in the number of notifications regarding birth defects in the four maternity hospitals when compared to previous years and to the records of São Paulo as a whole. The web-based referral and counter-referral method was efficient. The improvement in quantity as well as in quality of field 34 demonstrates the important presence of a geneticist doctor, even if only through long-distance aid to the pediatrician in the maternity hospital. The referral and counter-referral system promotes agility, providing a better service for patients and their family members at the Public Health System.