Navegando por Palavras-chave "Dermatitis"
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- ItemAcesso aberto (Open Access)Atopic dermatitis and vitamin D: facts and controversies(Soc Brasileira Dermatologia, 2013-11-01) Mesquita, Kleyton de Carvalho; Igreja, Ana Carolina de Souza Machado; Costa, Izelda Maria Carvalho [UNIFESP]; Universidade de Brasília (UnB); Fed Dist Hlth State Dept SES DF; Universidade Federal de São Paulo (UNIFESP)Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. in this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.
- ItemAcesso aberto (Open Access)Avaliação da eficácia e segurança do tacrolimo pomada 0,03% no tratamento da dermatite atópica em pacientes pediátricos(Sociedade Brasileira de Dermatologia, 2008-12-01) Gontijo, Bernardo; Duarte, Ida A. Gomes; Sittart, José Alexandre de Souza; Pires, Mario Cezar; Takaoka, Roberto; Cestari, Silmara da Costa Pereira [UNIFESP]; Cestari, Tania Ferreira; Aun, Wilson Tartuce; Oliveira, Zilda Najjar P. de; La Scala, Cintia Sayuri Kurokawa [UNIFESP]; Universidade Federal de Minas Gerais Hospital das Clínicas; Santa Casa de São Paulo Clínica de Dermatologia; Hospital do Servidor Público Estadual de São Paulo; Complexo Hospitalar de Guarulhos; Oregon Health Science University; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio Grande do Sul Hospital Clínicas de Porto AlegreBACKGROUND: Tacrolimus ointment has been shown to be effective in treatment of atopic dermatitis. OBJECTIVES: To evaluate the efficacy and safety of 0.03% tacrolimus ointment (Protopic®) in pediatric patients with mild, moderate and severe atopic dermatitis. METHODS: Open, non-comparative, multicentric study carried out in Brazil. 174 patients (ages from two to 10) with mild to severe atopic dermatitis were included. Patients were instructed to apply Protopic® twice a day for six weeks. Primary efficacy criterion was clinical improvement > 90% assessed by the physician (Clinical Response Global Evaluation Scale). Other efficacy criteria included reduction of the Eczema Area Severity Index (EASI), decrease of the affected body surface area (%BSA) and evaluation of the itching by the patients or their guardians (visual analogical scale). Safety was evaluated by adverse events reported by patients and/or guardians or by investigators. RESULTS: Thirty-three percent of patients showed clinical improvement > 90%. 45.5% of patients (1st week) decreased EASI and 61.8% (6th week) (p<0,001). %BSA decreased 30.4% and 55.5% in the first and sixth week. Improvement was also significant when measured by itching (p<0,001). Most frequentadverse effects were: burning and itching. CONCLUSION: 0.03% tacrolimus ointment is a safe and effective therapy for mild to severe atopic dermatitis in pediatric patients.
- ItemAcesso aberto (Open Access)Efeito do uso de lente escleral cosmética na sensibilidade tátil corneal em phthisis bulbi(Conselho Brasileiro de Oftalmologia, 2004-10-01) Lucci, Lucia Miriam Dumont [UNIFESP]; Itami, Cristina Nagako [UNIFESP]; Alves, Rosana Francisco [UNIFESP]; Montesano, Fabio Tadeu [UNIFESP]; Osaki, Midori Hentona [UNIFESP]; Sant'anna, Ana Estela B. P.p. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To compare corneal sensitivity between normal eyes and those whith phthisis bulbi and also to analyze the alterations of corneal sensitivity in phthisis bulbi induced by wearing ocular prosthesis. METHODS: Prospective study of 23 patients with unilateral phthisis bulbi. Bilateral cornea sensitivity was evaluated using the Cochet-Bonnet esthesiometer before and after 3 months of wearing ocular prosthesis. RESULTS: In all patients, corneal sensitivity of the eye with phthisis bulbi was lower than that of the normal eye (control). In 96% there was decrease of corneal sensitivity after adaptation of ocular prosthesis. CONCLUSION: After wearing ocular prosthesis, there is a reduction in corneal sensitivity in phthisis bulbi. The pathophysiology seems to be the same as that found in contact lens wearers.
- ItemAcesso aberto (Open Access)Livro sobre cuidados com dermatite associada à incontinência em recém-nascido, criança, adulto e idoso(Universidade Federal de São Paulo (UNIFESP), 2020-11-27) Raposo, Mayara Leticia Matos De Menezes [UNIFESP]; Blanes, Leila [UNIFESP]; Universidade Federal de São PauloIntroduction: Incontinence-Associated Dermatitis (IAD) is an inflammation of the skin caused by its prolonged contact with urine and/or feces. It affects all age groups, especially at the extremes of age. The management of IAD is a major challenge for health professionals. Thus, it is necessary to develop an educational resource containing the most relevant information about management of IAD at all stages of life. Objective: To develop and validate a book on the management of IAD in newborns, children, adults, and older adults. Methods: A descriptive exploratory study. The chapters of the book were defined after a search for studies published since 2009 in the PubMed/Medline, LILACS, BDENF, and EMBASE databases, using the keywords: adult, child, dermatitis, diaper rash, urinary incontinence, fecal incontinence, and aged. The written content and illustrations were then created. Upon completion, the book was validated by experts through the Delphi technique and the Content Validity Index was calculated. Results: After the review of the literature, the book chapters were defined and text content was written and proofread to improve grammar and readability. The illustrations were then included and the book layout was designed. The book was validated by seven experts through two rounds of consultation, achieving a 96% level of agreement among them. Conclusion: The book on the Management of Incontinence-Associated Dermatitis in newborns, children, adults, and older adults was developed and validated.
- ItemAcesso aberto (Open Access)Manual de cuidados com a pele para os privados de liberdade no sistema prisional do Estado de São Paulo(Universidade Federal de São Paulo (UNIFESP), 2018-08-16) Moreira, Daniela Tinti [UNIFESP]; Blanes, Leila [UNIFESP]; Schmidt, Christiane Steponavicius Sobral [UNIFESP]; http://lattes.cnpq.br/7996290670653478; http://lattes.cnpq.br/1898450330418640; http://lattes.cnpq.br/6309662850048221; Universidade Federal de São Paulo (UNIFESP)Introduction: Brazil has the third largest prison population in the world. Studies on the health status of people in prison are recent and describe the presence of infectious diseases, including infectious skin diseases in prisons in Canada, Switzerland, and Nigeria. Considering that some skin diseases can be prevented, the development of educational and preventive strategies, such as the use of educational manuals, is necessary. Objectives: To develop and to validate a manual of skin care for persons deprived of liberty in the São Paulo State Prison System. Methods: The study was approved by the Research Ethics Committees of UNIFESP (certificate no. CAAE 74601417.2.0000.5505) and of the State Department of Prison Administration (certificate no. CAAE 74601417.2.3001.5563). This descriptive study on the development and validation of a manual was carried out in the following steps: novelty search, literature search, data collection from medical records, content production, validation by an expert panel using the Delphi technique, evaluation by the target-users, and distribution. Results: The validation by the expert panel reached an overall content validity index (CVI) of 1.0 in two rounds of the Delphi technique and the evaluation by persons deprived of liberty showed an agreement of 98.57%. The manual has 31 pages, eight topics, 12 subtopics, and 29 illustrations. It was introduced to the people in prison through an expository presentation at the “Nestor Canoa” Prison in Mirandópolis (Brazil). Conclusion: A manual of skin care was developed and validated for persons deprived of liberty in the São Paulo State Prison System.
- ItemAcesso aberto (Open Access)Risk factors for atopic eczema in school children(Instituto de Medicina Integral Prof. Fernando Figueira, 2005-03-01) Wandalsen, Gustavo Falbo [UNIFESP]; Camelo-Nunes, Inês C. [UNIFESP]; Mello, Karyn C. [UNIFESP]; Naspitz, Charles Kirov [UNIFESP]; Solé, Dirceu [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVES: to study risk factors related to atopic eczema (AE) in school children of São Paulo. METHODS: 1972 parents or guardians of 6-7 years old children in the Southern Central area of São Paulo answered to a written questionnaire (standardized questionnaire of the International Study of Asthma and Allergies in Childhood plus a complementary questionnaire regarding family history of asthma and allergies, and exposure to environmental allergens). AE was defined by the presence of an itchy rash in the last year. Risk factors were analyzed through logical regression. RESULTS: the following factors were significantly associated with AE: history of maternal (OR: 4.1; 95%CI: 2.4 to 7.1) and paternal eczema (OR: 2.6; 95%CI: 1.4 to 5.0), dust in the child's bedroom (OR: 1.6; 95%CI: 1.1 to 2.4), lower maternal education (OR: 1.7; 95%CI: 1.1 to 2.7), rhinitis fever (OR: 1.7; 95%CI: 1.1 to 2.9) and wheezing in the last year (OR: 1.9; 95%CI: 1.2 to 2.8). CONCLUSIONS: our data suggest that AE has a specific pattern of inheritance. The presence of dust in the child's bedroom was the single environmental risk factor found. Diagnose of other allergic diseases, as well as the presence of recent symptoms were strongly associated with AE in children.
- ItemAcesso aberto (Open Access)The chronically ill student between waiting room and school(Universidade Federal do Espírito Santo, Cadernos de Pesquisa em Educação, 2017-12-12) Freitas, Marcos Cezar de [UNIFESP]; Zaninetti, Bruna; http://lattes.cnpq.br/6855478178963979The purpose of the article, which theoretically earned mainly from contributions from Erving Goffman, was to show the reality of chronically ill students. Methodologically it was made ethnographic research with chronically ill children in a public clinic extending the observation into four school units. This process of research was structured to show the situation of some students who have many faults, and that allowed analyzing the strategies they develop to organize their schoolwork. It was explored in detail the experience of living with atopic dermatitis. The results show that significant aspects of vulnerabilities are called social buildings, especially production of stigmas. Therefore the article states in its conclusions that the disadvantages of chronically ill children not only, but especially in school, do not