Navegando por Palavras-chave "Disease-Activity"

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    Atorvastatin reduced soluble receptors of tnf-alpha in systemic lupus erythematosus
    (Clinical & exper rheumatology, 2016) Ferreira, G. A.; Teixeira, A. L.; Calderaro, D. C.; Sato, E. I. [UNIFESP]
    Objective The aim of this study was to evaluate the efficacy of atorvastatin to reduce the plasma levels of TNF system molecules (TNF-alpha, sTNFR1 and sTNFR2) and to assess their association with risk factors for accelerate atherosclerosis and clinical disease activity scores in SLE patients. Methods In a previous study, 64 female SLE patients received 20 mg/day of atorvastatin and 24 SLE patients (non-treated group) were followed for 8 weeks. Plasma levels of TNF-alpha, sTNFR 1 and sTNFR 2 were measured by ELISA, at baseline and at the end of the study. Results The plasma levels of sTNFR1 and sTNFR 2 showed a positive correlation with SLEDAI score. We also found a positive correlation between TNF-alpha and sTNFR 1 levels and SLICC score. Patients with current nephritis and patients with anti-dsDNA antibodies presented higher sTNFR1 and sTNFR2 levels. Patients with abdominal obesity and arterial hypertension also had higher plasma levels of soluble receptors. At the end of 8 weeks, we observed a significant decrease in sTNFR1 plasma levels in patients receiving atorvastatin [median (percentile), 876.5 (717-1284 pg/ml) vs. 748 (629.6-917.3 pg/ml), p=0.03], without difference regarding TNF-alpha and sTNFR2 plasma levels. The SLEDAI and SLICC scores were independent determinants of the plasma levels of sRTNF1. Conclusion Atorvastatin reduced soluble receptors of TNF-alpha. The plasma levels of TNF-alpha, sTNFR1 and sTNFR2 may play a role in SLE activity and atherosclerosis, and might be evaluated as targets for new therapies.
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    Quality of life in spondyloarthritis: analysis of a large brazilian cohort
    (Elsevier science inc, 2016) Ribeiro, Sandra L. E.; Albuquerque, Elisa N.; Bortoluzzo, Adriana B.; Goncalves, Celio R.; Braga da Silva, Jose Antonio; Ximenes, Antonio Carlos; Bertolo, Manoel B.; Keiserman, Mauro; Menin, Rita; Skare, Thelma L.; Carneiro, Sueli; Azevedo, Valderilio F.; Vieira, Walber P.; Bianchi, Washington A.; Bonfiglioli, Rubens; Campanholo, Cristiano; Carvalho, Hellen M. S.; Costa, Izaias P.; Pinto Duarte, Angela L. B.; Kohem, Charles L.; Leite, Nocy H.; Lima, Sonia A. L.; Meirelles, Eduardo S.; Pereira, Ivelnio A.; Pinheiro, Marcelo M. [UNIFESP]; Polito, Elizandra; Resende, Gustavo G.; Rocha, Francisco Airton C.; Santiago, Mittermayer B.; Sauma, Maria de Fatima L. C.; Valim, Valeria; Sampaio-Barros, Percival D.
    Objective: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). Methods: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: The mean ASQoL score was 7.74 (+/- 5.39). When analyzing the specific diseases in the SpA group, the ASQoL scores did not present statistical significance. Demographic data showed worse scores of ASQoL associated with female gender (p = 0.014) and African Brazilian ethnicity (p <0.001). Regarding clinical symptoms, buttock pain (p = 0.032), cervical pain (p <0.001) and hip pain (p = 0.001), were statistically associated with worse scores of ASQoL. Continuous use of nonsteroidal anti-inflammatory drugs (p < 0.001) and biologic agents (p = 0.044) were associated with higher scores of ASQoL, while the other medications did not interfere with the ASQoL scores. Conclusion: In this large series of patients with SpA, female gender and African-Brazilian ethnicity, as well as predominant axial symptoms, were associated with impaired quality of life. (C) 2015 Elsevier Editora Ltda. All rights reserved.