Navegando por Palavras-chave "Drug Stability"

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    Estabilidade do cloridrato de vancomicina empregado na técnica de selo com antimicrobianos para descontaminação de cateteres intravenosos centrais
    (Universidade Federal de São Paulo (UNIFESP), 2019-08-29) Barros, Daniele Porto [UNIFESP]; Peterlini, Maria Angelica Sorgini [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Bloodstream infection related to central lines catheter is a frequent complication in children undergoing bone marrow transplantation, and the use of an antimicrobial lock technique, such as vancomycin hydrochloride in combination with sodium heparin is recommended as an adjunct to treatment. However, there is little evidence of the stability of the drugs used. Objectives: To verify the concentration and stability of vancomycin hydrochloride and sodium heparin solutions similar to those used in the antimicrobial lock technique, according to the influence of time and temperature. Methods: Experimental research developed under controlled environmental conditions. The hydrogen potential (pH), the osmolality and the concentration of vancomycin hydrochloride (500 mg), saline solution and sodium heparin (5,000 U.I.) were analized separately and in association, resulting in 282 analyzes. The concentration was verified by means of high performance liquid chromatography, the method being validated following the recommended guidelines for selectivity, linearity, precision and accuracy parameters. Vancomycin hydrochloride was reconstituted in distilled water (AD), diluted in saline solution and associated with sodium heparin, resulting in a concentration of 5 mg/mL of the antimicrobial and 100 U.I./mL of the anticoagulant. The solutions were conditioned in bottles of amber glass, at temperatures of 22° C and 37° C and the analyzes performed at the initial moment (T0), three (T3), eight (T8) and 24 hours (T24) after preparation. The data were analyzed according to mean and standard deviation, and one-way ANOVA, Kolmogorov-Smirnov, with Bonferroni correction (p≤0.05) was used. Results: Descriptive analysis of pH and osmolality of the solutions evidenced variation without statistically significant difference, except for osmolality of SF (p=0.022). The pH values of dilute vancomycin hydrochloride solutions, as well as in combination with sodium heparin at 22° C, showed statistically significant variation (p<0.001). The diluted antimicrobial solutions at 37° C resulted in a pH of 3,73 (± 0.02) in T0 at 3,68 (± 0.02) in T24 (p=0.004), and in the association 3,80 (±0.02) in T0 at 3,78 (±0.01) in T24 (p=0.389). The concentration of the diluted vancomycin hydrochloride at 22° C resulted in 5,10 (±0,08) in T0 at 5,12 (±0,07) mg/mL in T24 (p<0.001); and associated heparin sodium from 5,09 (±0.19) in T0 to 4,82 (±0.08) mg/mL in T24 (p<0.001). The diluted antimicrobial solutions at 37° C resulted in a concentration of 4,89 (±0.03) in T0 at 4,92 (±0.14) in T24 (p<0.001); the association of the drugs in 4,75 (±0.09) in T0 at 4,85 (±0.06) mg/mL in T24 (p=0.001). By analyzing the physical aspect of the solutions containing vancomycin hydrochloride and sodium heparin, precipitate formation was observed in T3, both at 22º C and 37º C. Conclusion: Vancomycin hydrochloride presented significant changes in the experimental situations studied, however. , the concentration variation was less than 10% in all experimental situations. The association of the antimicrobial with the anticoagulant resulted in pharmaceutical stability, but with physical incompatibility.
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    Hydrogen-Ion Potential of Antibiotics According to the Environment Factors Temperature and Luminosity
    (Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo, 2010-04-01) Crepaldi, Renata Maria Coelho; Monteiro, Cíntia [UNIFESP]; Peterlini, Maria Angélica Sorgini [UNIFESP]; Pedreira, Mavilde da Luz Gonçalves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The objective of this experimental study was to measure the pH of antibiotics administered by intravenous infusion - ceftriaxone sodium, vancomycin hydrochloride, metrodinazole, penicillin G potassium and amikacin sulfate - after reconstitution with sterile water and dilution with NaCl 0.9% or dextrose 5% in water, according to temperature and luminosity of the environment. The results showed that variation in the drugs' pH was less than 1.0 value and that some antibiotics remained acidic after dilution and maintained this chemical profile in all situations studied, suggesting that the studied environmental factors did not change the solutions' acid base characteristic. Some pH values measured characterize risk for the development of chemical phlebitis and infiltration, and it is important for clinical practice to emphasize the profile of intravenous solutions of antibiotics, considering method of dilution, and time to infusion.