Navegando por Palavras-chave "Dysplasia"
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- ItemAcesso aberto (Open Access)Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis(Sociedade Brasileira de Coloproctologia, 2014-09-01) Baldin Júnior, Antônio; Telles, José Ederaldo Queiroz [UNIFESP]; Bonardi, Renato De Araújo; Amarante, Heda Maria Barska Dos Santos; Baldin, Rosimeri Kuhl Svoboda; Universidade Federal do Paraná (UFPR); Universidade Federal do Paraná (UFPR) Hospital de Clínicas Coloproctology Unit; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Paraná (UFPR) Hospital de Clínicas; Universidade Federal do Paraná (UFPR) Department of Clinical Pathology; Universidade Federal do Paraná (UFPR) Department of Surgery; Universidade Federal do Paraná (UFPR) Department of Internal MedicineBackground: The association between ulcerative colitis and adenocarcinoma determined strategies for patient follow-up and early detection of dysplastic and neoplastic lesions. Aims: To analyze the incidence of dysplasia in patients with ulcerative colitis, comparing clinical data of patients with and without dysplasia and check immunohistochemical expression of p53 protein in dysplasias. Materials and methods: We analyzed biopsy samples and clinical data of 124 patients with ulcerative colitis at Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Results: Dysplasia incidence was low (9.67%) and all cases with low-grade dysplasia. Patients clinical data comparison with and without dysplasia did not show significant statistical differences with regard to the race, age at the start of the disease, age at last biopsy, duration and anatomic extent of ulcerative colitis. Significant difference was found between males and females with predominance of males (58.34%) for dysplasia. Seventeenth biopsy samples of 12 patients with dysplasia, 5 (29.4%) were p53 positive. Conclusions: From these results it is concluded that the incidence of dysplasia was low, higher in males and there was positivity of p53 protein in dysplasia.
- ItemSomente MetadadadosImmunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women(Funpec-editora, 2016) Rodrigues, L. C. [UNIFESP]; de Gois Speck, N. M. [UNIFESP]; de Azevedo Focchi, G. R. [UNIFESP]; Schimidt, M. A. [UNIFESP]; Marques, R. M. [UNIFESP]; Lascasas Ribalta, J. C. [UNIFESP]The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women.
- ItemSomente MetadadadosPrevalência de displasia do desenvolvimento do quadril em crianças nascidas no Hospital Municipal e Maternidade Escola Dr. Mário de Moraes Altenfelder Silva(Universidade Federal de São Paulo (UNIFESP), 2020-09-24) Motta, Giovanna Galvao Braga [UNIFESP]; Iared, Wagner [UNIFESP]; Universidade Federal de São PauloBackground: There is no population study in the medical literature that has assessed the prevalence of Developmental Dysplasia of the Hip in Brazil. An estimate published in 1988 is a prevalence close to 1.1%, based on the meta-analysis and logistic regression protocols analyzed. Objective: To evaluate the prevalence of developmental dysplasia of the hip in a sample of population of the city of São Paulo, in children aged zero to three days, born at the Hospital and Maternity School Dr. Mário by Moraes Altenfelder Silva. Methods: We conducted an observational study to assess the prevalence of Developmental Dysplasia of the Hip diagnosed by the Graf method and to verify its correlation with the risk factors related to the literature. Results: A total of 678 children underwent an ultrasound examination of their hips (1356 hips). The prevalence of Developmental Dysplasia of the Hip in the group was 5.46% (37 children with Developmental Dysplasia of the Hip). Twenty-four children had unilateral dysplasia, with 3 on the right (8.1%) and 21 on the left (56.7%). 13 children had bilateral dysplasia. Of the 678 patients who comprised the sample, there were 356 females (52.5%), 364 white (53.7%), the rest composed of blacks, browns and yellows, 449 children born by natural birth (66%), 179 were in breech presentation at birth (26.4%), 302 were firstborn (44.5%), 19 had a positive family history of developmental dysplasia of the hip (2.8%), 4 twins (0.6%), 4 with positive Ortolani test (0.6%), no children with genetic or pathological syndrome. A logistic regression analysis registered odds ratios with statistical significance for the white with Odds Ratio (OR) of 2.561 [95% CI 1.07 to 6.11], multiparity with OR 3.50 [95% CI 1.62 to 7.38], female gender with OR 4.95 [95% CI 1.86 to 13,13] and breech presentation with OR of 2.03 [95% CI 1.01 to 4.11]. Conclusion: The study shows that the prevalence of developmental dysplasia of the hip in the sample is more than five times higher than the estimate in Brazil. The main risk factors associated with the highest risk of Developmental Dysplasia of Hip were female, breech presentation, firstborn and white race.