Navegando por Palavras-chave "Epitélio da córnea"
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- ItemAcesso aberto (Open Access)Efeito do mel e do soro autólogo na cicatrização do epitélio corneano em coelhos(Conselho Brasileiro de Oftalmologia, 2005-06-01) Malavazzi, Gustavo Ricci [UNIFESP]; Lake, Jonathan Clive; Dantas, Paulo Elias Correa; Universidade Federal de São Paulo (UNIFESP); Irmandade da Santa Casa de Misericórdia de São Paulo Departamento de Oftalmologia Seção de Córnea e Doenças ExternasPURPOSE: To evaluate the efficacy of pure honey and 20% autologous serum and BSS® in corneal epithelial healing in rabbits after 48 hours. METHODS: All solutions were applied after an epithelial removal of 13-millimeters diameter area. Areas of epithelial healing were studied at 12, 24 and 48 hours. The eyes were treated every four hours during 2 days. All treated eyes were assigned to a control group (contralateral eye) treated with a balanced saline solution. RESULTS: All studied groups were not significantly differents. In group one, the eyes treated with honey and the control were similar (p<0.87). In the second group the eyes treated with autologos serum and the control presented no difference in the mean score (p<0.072). CONCLUSION: Corneal epithelial healing in rabbits did not show improvement after application of either honey or autologous serum. It was possible to stabilish that the autologous serum treated eyes were clinicaly better than the control group but without statistical significance.
- ItemAcesso aberto (Open Access)Membrana amniótica no tratamento dos afinamentos corneais e esclerais(Conselho Brasileiro de Oftalmologia, 2003-01-01) Fairbanks, Daniella [UNIFESP]; Vieira, Luiz Antônio [UNIFESP]; Santos, Walner Daros dos [UNIFESP]; Attie, Greicie Cristina Guerra [UNIFESP]; Gomes, José Álvaro Pereira [UNIFESP]; Freitas, Denise de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina do ABCPURPOSE: To evaluate the use of amniotic membrane (AM) as an adjunct to the treatment of corneal and scleral thinnings. METHODS: Amniotic membrane was obtained at the time of cesarean section and was preserved at -80ºC in glycerol and cornea culture media at a ratio of 1:1. Seven eyes from 7 patients were divided into Group 1: neurotrophic ulcers secondary to herpes simplex virus keratitis (2 cases), after corneal transplantation (1 case), and post palpebral radiation (1 case); and Group 2: scleral thinning after pterygium surgery with (2 cases) or without (1 case) beta-therapy. All cases underwent amniotic membrane transplantation to restore thickness and promote epithelialization. RESULTS: Mean follow-up time was 12 months (range, 11-15 months). One case of neurotrophic ulcer secondary to radiotherapy was unsuccessful. A successful outcome was observed in the other 6 cases. Regarding visual acuity, 1 case improved and the other 6 cases remained unchanged. The mean epithelialization time was 26.6 ± 5.8 days for group 1 and 10.6 ± 4.0 days for group 2. CONCLUSIONS: The use of amniotic membrane represents a useful alternative to ocular surface reconstruction in corneal and scleral thinning. More cases and a longer follow up are necessary to better evaluate this procedure.
- ItemAcesso aberto (Open Access)Toxicidade córneo-conjuntival do colírio de iodo-povidona: estudo experimental(Conselho Brasileiro de Oftalmologia, 2003-06-01) Santos, Namir Clementino [UNIFESP]; Sousa, Luciene Barbosa de [UNIFESP]; Freitas, Denise de [UNIFESP]; Rigueiro, Moacyr Pezati [UNIFESP]; Scarpi, Marinho Jorge [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To evaluate ocular toxicity of povidone-iodine eye drops at a concentration of 2.5% and 0.5% and to investigate the effects on corneal epithelial wound healing and histopathological alterations. METHODS: Each group (PVP-I 2.5% and 0.5%) consisted of 20 rabbits. A central circular corneal epithelial defect of 6.5 mm diameter was created and the povidone-iodine eyedrops (2.5% and 0.5) instilled in the right eye and distilled water in the left eye (control) of each rabbit, every hour, during 3 days. Biomicroscopical examinations were performed every day, focussing on the corneoconjunctival surface and the diameter of the lesion, using fluoresceine eye drops, photodocumentation, and a computerized image analyzer. After the third day the rabbits were sacrified and the excised corneas histopathologically evaluated. Statistical evaluation was performed using Friedman, Mann-Witney, Wilcoxon, Fisher and Chi-squared tests. RESULTS: Povidone-iodine eye drops, at a concentration of 2.5%, caused an increase in the wound healing time (p= 0.087) and conjuntivitis in 100% of the eyes with mucous secretion in 80%, punctate ceratitis in 40%, and discrete stromal edema in 10% of the cases. The histopathological examination showed corneal ulcers and vacuolic degeneration of the endothelial layer in 100%, as well as an inflammatory infiltrate with eosinophils in 80% of the cases. The eyes treated with povidone-iodine eye drops at a concentration of 0.5% and the control eyes showed complete epithelial wound healing after 72 hours, and histopathologically normal epithelization. Only in one case, a discrete perilimbar leucocytic infiltrate was observed. CONCLUSION: The ocular toxicity of povidone-iodine eye drops is concentration-dependent. The use of the eye drop at a concentration of 2.5% is not adequate for daily and repetitive use. In contrast, at a concentration of 0.5% no toxicity was observed.
- ItemAcesso aberto (Open Access)Uso de mitomicina C tópico no tratamento da neoplasia intra-epitelial córneo-conjuntival e carcinoma espinocelular conjuntival: resultados preliminares(Conselho Brasileiro de Oftalmologia, 2003-10-01) Ballalai, Priscilla Luppi [UNIFESP]; Gomes, José Álvaro Pereira [UNIFESP]; Santos, Myrna Serapião dos [UNIFESP]; Freitas, Denise de [UNIFESP]; Erwenne, Clélia Maria [UNIFESP]; Rigueiro, Moacyr Pezati [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: The purpose of this study is to evaluate the safety, efficacy and recurrence after topical use of mitomycin C (MMC) for primary or recurrent corneal-conjunctival intraepithelial neoplasia (CIN) and recurrent squamous cell carcinoma (SCC). METHODS: Two groups of patients were trated. Group 1 patients with primary or recurrent CIN were treated with topical 0.02% MMC, qid for 28 days. Group 2, patients with recurrent SCC, were treated with topical 0.02% MMC, qid for 21 to28 days. RESULTS: Eight patients with CIN and 1with SCC had a total regression of the lesion and all of them had negative control exfoliative cytology for neoplastic cells. One patient with CIN and 2 with SCC had partial regression of the lesions, which were excised surgically, and the pathology was negative for neoplasia. Side effects were transient and subsided after descontinuation of the treatment. There was no recurrence of the lesions on a mean follow-up of 24.9 months. CONCLUSION: The preliminary results of this study suggest that the use of the topical MMC is safe and efficient for the treatment of primary and recurrent CIN and recurrent SCC, although it did not prevent surgery in almost all cases of CEC. There were no recurrences during the follow-up. Further studies with more patients and longer follow-up are necessary to confirm this results.