Navegando por Palavras-chave "Erupção por droga"
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- ItemAcesso aberto (Open Access)Acne induzida por amineptina(Sociedade Brasileira de Dermatologia, 2009-02-01) Guedes, Antonio Carlos Martins [UNIFESP]; Bentes, Aline Almeida; Machado-Pinto, Jackson; Carvalho, Maria De Lourdes Ribeiro De; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Minas Gerais Acadêmica de Medicina; Faculdade de Ciências Médicas de Minas Gerais Casa de Belo Horizonte Clínica Dermatológica; Universidade Federal de Minas Gerais Instituto de Ciências BiológicasRelata-se um caso grave de lesões acne-símile associada a amineptina (Survector®), proeminentes na face e dorso, acometendo outros sítios não afetados pela acne vulgar, como períneo, braços e pernas. As lesões apareceram após a auto-administração crônica de altas doses do medicamento. Lesões ceratoacantoma-símile também estavam presentes, tendo as lesões menores resposta satisfatória ao tratamento com imiquimod tópico. O relato é significativo pela raridade da doença.
- ItemAcesso aberto (Open Access)DRESS: clinicopathological features of 10 cases from an University Hospital in São Paulo(Sociedade Brasileira de Dermatologia, 2012-10-01) Botelho, Luciane Francisca Fernandes [UNIFESP]; Higashi, Viviane Shinsato [UNIFESP]; Padilha, Maria Helena Valle de Queiroz [UNIFESP]; Enokihara, Mílvia Maria Simões e Silva [UNIFESP]; Porro, Adriana Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)BACKGROUND: Drug reaction with eosinophilia and systemic symptoms is a severe form of drug-induced reaction with multiorgan involvement. OBJECTIVES: The aim of this study is to evaluate the epidemiological, clinical and pathological features and prognosis of this drug reaction among patients seen at a dermatology service. METHOD: Retrospective review of medical records of ten patients diagnosed with drug reaction with eosinophilia and systemic symptoms at the Federal University of São Paulo, from august 2008 to may 2011. RESULTS: Phenytoin was the leading cause of drug reaction with eosinophilia and systemic symptoms in our cases, followed by allopurinol. Abnormal liver function tests were observed in 7 patients and renal function impairment in 2 patients. In all cases, patients were hospitalized and the culprit drug was withdrawn. The main treatment was systemic corticosteroid. Drug reaction with eosinophilia and systemic symptoms resulted in death in 2 cases. The causes of death were septic shock and hepatic failure. CONCLUSION: Our mortality rate of 20%, supports that drug reaction with eosinophilia and systemic symptoms is a severe form of drug-induced reaction and must be recognized by all dermatologists.