Navegando por Palavras-chave "Exercise capacity"

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    Capacidade de exercício e seu valor prognóstico no pós-operatório de cirurgia cardíaca
    (Pontifícia Universidade Católica do Paraná, 2012-12-01) Bueno, Flávia Regina [UNIFESP]; Corrêa, Fernanda Rocha [UNIFESP]; Alves, Mariana Agnes da Silva [UNIFESP]; Bardin, Marcela Grigol [UNIFESP]; Modesto, Janaína Aparecida [UNIFESP]; Dourado, Victor Zuniga [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    INTRODUCTION: The prognostic value of exercise capacity in patients undergoing coronary artery bypass grafting (CABG) needs clarification. OBJECTIVES: To assess exercise capacity and its prognostic value in patients with coronary artery disease undergoing elective CABG. MATERIALS AND METHODS: We evaluated 21 patients and 29 controls. Two incremental shuttle walk test (ISWT) and two tests of 6-min walk test (6MWT) were performed randomly on alternate days. The handgrip strength (FPM) was also evaluated. RESULTS: The FPM in percentages (78.4 ± 16 vs. 97.2 ± 15%), the 6MWT in meters (412 ± 79 vs. 601 ± 7 m) and percentage values (72 ± 13 vs. 110 ± 11%) and the ISWT in meters (257 ± 90 vs. 517 ± 138 m) and percentage values (53 ± 16 vs. 108 ± 16%) were significantly (p < 0.05) lower in patients. Eleven patients had postoperative complications (group C) and 10 had a good outcome (group SC). The group C showed significantly (p < 0.05), older age (57 ± 6 vs. 71 ± 7 years old), FPM lower (33 ± 6 vs. 9 ± 41 kgf) and ISWT lower (208 ± 81 vs. 311 ± 66 m). There were no significant differences for the 6MWT. Logistic regression analysis comparing the ISWT and 6MWT selected ISWT as a determinant of prognosis of patients (p = 0.04). CONCLUSION: Patients waiting for elective CABG have significantly reduced exercise capacity and ISWT had significant prognostic value discriminating patients with postoperative complications.
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    Inhaled Treprostinil in Pulmonary Hypertension Associated with Lung Disease
    (Springer, 2018) Faria-Urbina, Mariana; Oliveira, Rudolf Krawczenko Feitoza de [UNIFESP]; Agarwal, Manyoo; Waxman, Aaron B.
    Pulmonary hypertension (PH) in the setting of parenchymal lung disease adversely affects quality of life and survival. However, PH-specific drugs may result in ventilation/perfusion imbalance and currently, there are no approved PH treatments for this patient population. In the present retrospective study, data from 22 patients with PH associated with lung disease treated with inhaled treprostinil (iTre) and followed up clinically for at least 3 months are presented. PH was defined by resting right heart catheterization as a mean pulmonary artery pressure (mPAP) >= 35 mmHg, or mPAP >= 25 mmHg associated with pulmonary vascular resistance >= 4 Woods Units. Follow-up evaluation was performed at the discretion of the attending physician. From baseline to follow-up, we observed significant improvement in functional class (n = 22, functional class III-IV 82 vs. 59%, p = 0.041) and 6-min walk distance (n = 11, 243 +/- 106 vs. 308 +/- 109