Navegando por Palavras-chave "Fenoterol"

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    Ensaio clínico controlado e meta-análise sobre a adição di brometo de ipratrópico ao fenoterol no tratamento da crise grave de asma
    (Universidade Federal de São Paulo (UNIFESP), 1997) Diccini, Solange [UNIFESP]; Silva, Clystenes Odyr Soares [UNIFESP]
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    Ensaio clínico, aberto, controlado sobre a adição de brometo de ipratrópio ao fenoterol no tratamento da crise de asma em adultos
    (Sociedade Brasileira de Pneumologia e Tisiologia, 1999-12-01) Diccini, Solange [UNIFESP]; Silva, Clystenes Odyr Soares [UNIFESP]; Nakatani, Jorge [UNIFESP]; Pereira, Carlos Alberto de Castro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Repeated dosis of inhaled b2-agonists have been used in the treatment of acute asthma. The effect of added ipratropium bromide (IB) to b2-agonist is controversial in adults. OBJECTIVE: To evaluate if addition of IB to fenoterol, in repeated doses, induces a greater bronchodilation, a greater reversion of the attack, and discharge from emergency unit in adults with acute severe asthma. SETTING: Pneumology Emergency Department, UNIFESP-Hospital São Paulo, in the period from July 1995 to February 1997. TYPE OF STUDY: Open, randomized and parallel study. Discharge from the hospital: FEV1 and PEF > 60% of the predicted value. METHODS: 120 patients with FEV1 and PEF < 50% of the predicted value were divided into two groups (N = 60): fenoterol (F) and ipratropium bromide + fenoterol (IBF). Each group received inhalation treatment through a metered-dose inhaler (MDI) attached to a holding chamber, administered at 30-minute interval, for a total of three treatments. In the group F four puffs of fenoterol (400 mg) were administered, and in the IBF group, 160 mg of BI and 400 mg of fenoterol (four puffs). RESULTS: The patients did not differ from basal PEF (F = 36 ± 7% vs IBF = 35 ± 9% predicted) and basal FEV1 (F = 33 ± 9% vs IBF = 32 ± 9% predicted). Thirty-two patients of group F and 33 of group IBF were discharged from hospital after the inhalation treatment. The final FEV1 and PEF after inhalation treatments were F = 60 ± 13% vs IBF = 61 ± 11% e F = 74 ± 18% vs IBF = 77 ± 13% (NS). CONCLUSION: The addition of ipratropium bromide to fenoterol results in insignificant functional effect and without clinical impact in the treatment of acute asthma in adults.
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    Estudo comparativo de diferentes métodos de administração de uma droga beta-agonista (fenoterol), na crise de asma brônquica, na criança
    (Universidade Federal de São Paulo (UNIFESP), 1989) Scalabrin, Deolinda Maria Felin [UNIFESP]
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    Protective effects of different doses of inhaled fenoterol on methacholine-induced bronchoconstriction in asthmatic children
    (Associação Paulista de Medicina - APM, 1998-11-01) Gomez, Irma Douglas [UNIFESP]; Silva, Marilia De Dirceu [UNIFESP]; Bueno, Maria Poliana [UNIFESP]; Solé, Dirceu [UNIFESP]; Naspitz, Charles Kirov [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: To evaluate the protective effect of different doses of inhaled fenoterol (F) on bronchoconstriction induced by methacholine (M).DESIGN: randomized double-blind study.SETTING: Referrence center.PARTICIPANTS: 9 children (aged from 7 to 15 years old), with mild or moderate asthma and allergic to D. pteronyssinus.INTERVENTION: On the first day, the M concentration necessary to induce a 20% fall in the forced expiratory volume in the first second (FEV1; PC20FEV1) was determined using closed circuit inhalation (De Vilbiss 646). On subsequent days, the children inhaled a dose of F (25 or 50 or 100 or 200 µg) through the same circuit and, after 15 minutes the FEV1 was measured, becoming the basal value. Bronchoprovocation was then initiated using the concentration prior to the PC20FEV1 of the first day and continuing until there was a 20% fall in the FEV1. This concentration was the new PC20FEV1.RESULTS: F in a dose of 25 µg protected 2 of the 9 children, in a dose of 50 mg protected 4 of the 9 and in doses of 100 and 200 µg protected all children. We did not observe any relationship between the magnitude of the bronchodilation and bronchoprotection induced by the inhalation of F. CONCLUSIONS: Our results suggest that a dose of 100 µg of F is capable of inducing bronchoprotection in children with mild/moderate asthma.