Navegando por Palavras-chave "Ferida Cirúrgica"

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    Fração vascular estromal associada à matriz dérmica acelular na cicatrização de feridas cutâneas em coelhos
    (Universidade Federal de São Paulo (UNIFESP), 2020-03-31) Carvalho Junior, Jose Da Conceicao [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Universidade Federal de São Paulo
    Introduction: Several methods have been studied to optimize the use of the Acelular Dermal Matrix (ADM) in the healing of skin wounds, with a new option being the Stromal Vascular Fraction (SVF). Objective: To evaluate the effects of the Stromal Vascular Fraction associated with the Acellular Dermal Matrix on the healing of skin wounds in rabbits. Method: 24 rabbits were divided into four groups (n = 6). Three 20 x 20 mm skin wounds were performed on the animals' backs, the only procedure being performed in the Control Group. In the ADM group the wounds were covered with ADM. In the SVF group 2 x 106 autologous SVF cells were injected into the wound margins and in the ADM/SVF group, SVF cells were injected and the wounds covered with ADM. The wounds were photographed for 21 days and biopsies were performed on 3, 14 and 21 days to assess skin thickness, quantify collagen, to evaluate the formation and diameter of new vessels. Results: There was no difference in healing time between groups. The ADM/SVF group showed greater thickness of the dermis and epidermis, a greater amount of type I and III collagen and a greater number and diameter of blood vessels when compared to the control group, ADM and SVF alone. Conclusion: Stromal Vascular Fraction associated with the Acellular Dermal Matrix, increased vascularization, the amount of collagen and the thickness of the skin, during the healing of cutaneous wounds in rabbits, without changing the time of wound closure.