Navegando por Palavras-chave "Fotoenvelhecimento da pele"

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    Estudo clínico-laboratorial para verificar e comparar eficácia e segurança do ácido retinoico a 0,05% em creme e a 5% em peelings superficiais no fotoenvelhecimento e carcinogênese do antebraço
    (Universidade Federal de São Paulo (UNIFESP), 2017-10-26) Sumita, Juliana Mayumi [UNIFESP]; Bagatin, Edileia [UNIFESP]; Miot, Hélio Amante [UNIFESP]; http://lattes.cnpq.br/2543633050941005; Universidade Federal de São Paulo (UNIFESP)
    Background: Topical use of retinoic acid in cream is the gold standard treatment for skin aging, particularly photoaging. To obtain the same results in less time, the peeling of retinoic acid was created, but there are few controlled studies on its effectiveness, limited to the improvement of the signs of photoaging and cutaneous hyperpigmentation. Objectives: Evaluate and compare efficacy and safety of retinoic acid at 0.05% and 5% (as a peeling agent) for photoaging and carcinogenesis of the forearm. Methods: Prospective clinical study of therapeutic intervention, randomized, comparative and evaluator blinded. Efficacy and safety evaluated by the participant's opinion, severity of photoaging, measurement of the viscoelastic properties of the skin, corneometry, profilometry, high frequency ultrasound, histological exams (Hematoxylin-Eosin and Verhoeff stainings) and immunohistochemistry (p53, bcl-2 , Ki67 and collagen I). Results: The two forearms of 24 participants were evaluated. Three efficacy parameters showed opposite effects of the two treatments. 1) The thickness of the stratum corneum decreased with 0.05% retinoic acid and increased with 5%. 2) The echogenicity of the dermis by ultrasonography increased with 0.05% and decreased with 5%. 3) Ki67 expression increased with 0.05% and decreased with 5%. The favorable opinion of the participant, improvement of the photoaging score, corneometry, profilometry, recovery of viscoelasticity, increase of papillary dermis thickness, reduction of solar elastosis, decrease of p53, increase of bcl-2 and collagen I were not different between them. There was good tolerability in both treatments. Conclusion: The results confirmed the safety and benefits of retinoic acid at 0.05% and 5%, but at different scopes. 0.05% retinoic acid reversed the signs of photoaging in the long term (elevation of the echogenicity of the dermis), reaffirming itself as a gold standard for the treatment of photoaging. Peeling of 5% retinoic acid reduced the risk of skin cancer in the short term (reduction of Ki67), and was shown as a promising method for adjuvant treatment of actinic keratoses and cancerization field.
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    Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial
    (Universidade Federal de São Paulo (UNIFESP), 2010-04-28) Haddad, Alessandra [UNIFESP]; Santos, Ivan Dunshee de Abranches Oliveira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    BACKGROUND: Photodynamic rejuvenation is the term used to the treatment of actinic keratosis and photodamage with photodynamic therapy. OBJECTIVE: Evaluate the efficacy of photodynamic therapy with aminolevulinic acid and intense pulsed light in the treatment of actinic keratosis and photodamage. METHODS: Fourty three patients mean age 71,3 years, were randomized in three groups: Control (IPL 18J); Treatment I (ALA+ IPL 16J); and Treatment II ( ALA+ IPL 18J) and evaluated clinically an photographically by two observers in Pre, 48hs, 8 weeks and 12 weeks Post-Treatment using Griffth’s Photonumeric Scale. Five actinic keratosis were marked as target in Pre-Treatment and biopsies Pre and Post-Treatment were done in one lesion to evaluate atypias and loss of cellular polarity. RESULTS: Non parametric tests showed marked improvement in mottled pigmentation, texture fine wrinkles in Groups Treatment I and II. In Control Group improvement only in mottled pigmentation. Actinic Keratosis clearance in Groups Treatment I and II were 51,2% and 68,4% respectively, whereas in Group Control it was 5%. In relation to Control Group, Groups Treatment I and II showed significant reduction of atypias and improvement in loss of cellular polarity. CONCLUSIONS: Photodynamic therapy with aminolevulinic acid and intense pulsed light is effective in the treatment of photodamage and actinic keratosis. The resolution of actinic keratosis was better with higher levels of energy.