Navegando por Palavras-chave "Glaucoma, open-angle"
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- ItemAcesso aberto (Open Access)Análise discriminante dos pacientes portadores de glaucoma primário de ângulo aberto através do exame de Doppler colorido e do campo visual(Conselho Brasileiro de Oftalmologia, 2011-10-01) Ramos, Maria Helena Mandello Carvalhães [UNIFESP]; Bergés, Olivier; Prata Junior, João Antonio [UNIFESP]; Allemann, Norma [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fondation Ophtalmologique Adolphe Rothschild Le Service d'Imagerie; Universidade Federal do Triângulo Mineiro Faculdade de Medicina Departamento de OftalmologiaPURPOSE: To determine if variables from color Doppler and visual field exam could discriminate normal from glaucomatous eyes. METHODS: Prospectively, 36 patients with primary open-angle glaucoma (glaucoma group) and 20 normal volunteers (control group) were studied. Gender, age, central corneal thickness, intraocular pressure, Octopus automated perimetry global indices (mean defect and loss variance) and several parameters of the color Doppler (peak systolic velocity and resistivity index) were compared between groups. RESULTS: There was no statistically significant difference in age, central corneal thickness and intraocular pressure. Discriminant analysis showed that the variables: resistivity index (RI) in the short posterior ciliary artery (SPCA), mean defect (MD) and loss variance (LV) had presented significant influence for the positive diagnosis of glaucoma. The gotten discriminant function was: -3.637 + 0.109 x MD + 0.028 x LV + 4.325 x RI SPCA. Considering score -1.61, the probability of positive diagnosis of glaucoma was 90%. CONCLUSION: Through discriminant analysis it was possible to identify which of the color Doppler variables that associated to the visual field variables allowed differentiate normal from glaucomatous patients. These variables were: resistivity index in the short posterior ciliary artery, and the visual field variables, mean defect and loss variance.
- ItemAcesso aberto (Open Access)Biomicroscopia ultra-sônica em esclerectomia profunda: relato de caso(Conselho Brasileiro de Oftalmologia, 2008-06-01) Villas-bôas, Flávia; Allemann, Norma [UNIFESP]; Morales, Maira Saad Avila; Omi, Carlos Akira [UNIFESP]; Instituto Brasileiro de Oftalmologia e Prevenção à Cegueira; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Case report of a woman with the diagnosis of primary open-angle glaucoma who was submitted to a successful surgical procedure of deep sclerectomy in the right eye. In the postoperative period, at month 3, the surgical procedure was evaluated with ultrasound biomicroscopy (UBM) utilizing two distinct equipments (UBM 840-Zeiss; UBM-VUMAX-Sonomed), with 50-MHz transducers. The diagnostic method of ultrasound biomicroscopy can be utilized as a non invasive method to evaluate the internal architecture of the eye at the topography of deep sclerectomy. It allows to identify the anterior segment structures, their anatomical relationship, and also the intact trabecular-Descemet membrane and the intrascleral space. Ultrasound biomicroscopy showed to be useful in evaluating postoperative status of the surgical procedure.
- ItemAcesso aberto (Open Access)Concentração de proteínas no humor aquoso de pacientes com glaucoma primário de ângulo aberto em tratamento clínico(Conselho Brasileiro de Oftalmologia, 2007-03-01) Prata, Tiago dos Santos [UNIFESP]; Navajas, Eduardo Vitor [UNIFESP]; Melo Junior, Luiz Alberto Soares [UNIFESP]; Martins, João Roberto Maciel [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Belfort, Rubens Junior [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To compare total protein concentration in the aqueous humor of primary open-angle glaucoma and non-glaucomatous patients. METHODS: Aqueous humor samples were obtained from 22 patients just before trabeculectomy for clinically uncontrolled primary open angle glaucoma (POAG group). Aqueous humor (0.1 mL) was aspirated by inserting a 26-gauge needle into the anterior chamber. The same procedure was performed in 22 non-glaucomatous patients just before cataract surgery (control group). Immediately after collection, the aqueous humor was stored at -20°C. Aqueous humor total protein concentration was determined using a colorimetric assay. RESULTS: The geometric mean of total protein concentration of the aqueous humor samples was 32 mg/dL (range: 8-137 mg/dL) in the primary open angle glaucoma group and 16 mg/dL (range: 2-85 mg/dL) in the control group. The ratio of the protein concentration between the two groups was 2.0 (95% confidence interval: 1.3 to 3.2; p=0.003). CONCLUSIONS: The total protein concentration in primary open-angle glaucoma aqueous humor was approximately two times higher than that in non-glaucomatous subjects.
- ItemAcesso aberto (Open Access)Factors affecting the variability of the Heidelberg Retina Tomograph III measurements in newly diagnosed glaucoma patients(Conselho Brasileiro de Oftalmologia, 2010-08-01) Prata, Tiago dos Santos [UNIFESP]; Meira-Freitas, Daniel [UNIFESP]; Lima, Verônica Castro [UNIFESP]; Guedes, Lia Manis [UNIFESP]; Magalhães, Fernanda Pedreira [UNIFESP]; Paranhos Junior, Augusto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To determine factors associated with the test-retest variability of optic nerve head (ONH) topography measurements with confocal scanning laser ophthalmoscopy (CSLO) in newly diagnosed glaucomatous patients. METHODS: Consecutive patients with newly diagnosed primary open-angle glaucoma were prospectively enrolled. Patients presenting with any ocular disease other than glaucoma were excluded. All patients underwent CSLO using the Heidelberg Retina Tomograph III (HRT-III) in one randomly selected eye (three consecutive scans; performed by the same examiner). For each Heidelberg Retina Tomograph III parameter, repeatability was assessed using within subject standard deviation (Sw) and coefficient of variation (CVw), repeatability coefficient (RC) and intraclass correlation coefficient (ICC). Scatter plots and regression lines were constructed to identify which factors influenced test-retest measurement variability. RESULTS: A total of 32 patients were included (mean age, 65.4 ± 13.8 years). Most patients were female (65%) and white (50%). Among all Heidelberg Retina Tomograph III parameters evaluated, rim area and mean cup depth had the best measurement repeatability. Vertical cup-to-disc ratio (CDR, as determined by optic disc stereophotograph examination) was significantly associated (R²=0.21, p<0.01) with test-retest measurement variability. Eyes with larger CDR showed less variable measurements. Other factors, including age, disc area, central corneal thickness and intraocular pressure were not significant (p>0.14). CONCLUSION: Heidelberg Retina Tomograph III showed good test-retest repeatability for all ONH topographic measurements, mainly for rim area and mean cup depth. Test-retest repeatability seemed to improve with increasing CDR. These findings suggest that HRT-III topographic measurements should be cautiously interpreted when evaluating longitudinally glaucoma patients with early structural damage (small CDR).
- ItemAcesso aberto (Open Access)Glaucoma de pressão normal(Conselho Brasileiro de Oftalmologia, 2005-08-01) Tavares, Ivan Maynart [UNIFESP]; Mello, Paulo Augusto de Arruda [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); University of California Hamilton Glaucoma Center Department of Ophthalmology; MEC CAPESNormal tension glaucoma is an optic neuropathy in which the retinal nerve fiber layer thickness is reduced, the optic nerve is pathologically excavated, and the visual field is disturbed, although intraocular pressure is classified as normal. Patients with normal tension glaucoma are a heterogeneous group in which many systemic pathologic conditions may be present, and presenting ocular clinical signs that are difficult to be identified in the early stages of the disease. Treatment is more challenging than in hypertensive glaucomas. The authors sought to review the pathophysiology and differential diagnosis of this condition assessing vascular, rheumatic, neurological and genetic aspects that should be studied, as well as its treatment. The sources of references are PubMed (MEDLINE), LILACS and Cochrane Library (CENTRAL) databases.
- ItemAcesso aberto (Open Access)Importância da perimetria manual cinética na avaliação de pacientes com glaucoma avançado(Sociedade Brasileira de Oftalmologia, 2011-02-01) Moysés, Nadia Ajub; Souza, Elaine Caetano de; Omi, Carlos Akira [UNIFESP]; Hospital de Transplantes do Estado de São Paulo Dr. Euryclides de Jesus Zerbini Setor de Glaucoma; Instituto Paulista de Oftalmologia Especializada Setor de Glaucoma; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To evaluate the importance of Goldmann manual kinetic perimetry (MKP) in glaucomatous patients with advanced visual field loss in automated static perimetry (ASP) with Humphrey perimeter (HP). METHODS: The MKP with Goldmann perimeter (GP) was performed in patients with advanced primary open angle glaucoma with advanced visual field defect in the ASP with HP. A qualitative analysis was realized on the visual field extension in the Goldmann perimetry of these patients. RESULTS: The results are illustrated in a qualitative way. CONCLUSION: The MKP with GP was useful to complement the evaluation of the real campimetric condition of advanced primary open angle glaucomatous patients.