Navegando por Palavras-chave "Glucosamine"
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- ItemAcesso aberto (Open Access)Effects of glucosamine on the tibial epiphyseal disk of ovariectomized rats: morphologic and morphometric analysis(Faculdade de Medicina / USP, 2007-01-01) Maganhin, Carla Cristina [UNIFESP]; Toledo, Olga Maria Szymanski [UNIFESP]; Regina Ct, Gomes [UNIFESP]; Simões, Ricardo dos Santos [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Soares Junior, Jose Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); University of São Paulo Medical School of MedicineOBJECTIVE: The aim of this study was to analyze the effect of glucosamine sulfate on the tibial epiphyseal disk of the ovariectomized rats. METHODS: After ovariectomy (OVx), 28 female rats were randomly divided into 4 experimental groups with 7 animals each, treated as follows: OVx 21 - vehicle (NaCl 0.9%) 0.5 mL/day) for 21 days; OVx GS21 - 230 mg/kg/day glucosamine sulphate for 21 days; OVx 45 - treated with NaCl 0.9% as above for 45 days; and OVx - GS45230 mg/kg/day glucosamine sulphate for 45 days. Seven intact animals in the proestrous phase were used as controls (CG). Upon treatment completion, the animals were sacrificed and the left knee joint was dissected and prepared for histological analysis. RESULTS: The percentage of remaining cartilage in new bone of the CG; that found in THE OVx GS45 group was significantly less than that of the OVx 21, OVx GS21, and OVx 45 groups. The percentage of trabecular bone in proestrous animals was the highest. The OVx GS45 group showed higher values compared with the other ovariectomized groups. These results were paralleled by the findings regarding the cells of the proliferative zone, since the CG had the highest values, and the values of the OVx GS45 group were greater than those of the OVx 21, OVx GS21, and OVx 45 groups. CONCLUSION: Our studies suggested that glucosamine may stimulate tibial cartilage and bone growth after ovariectomy in rats.
- ItemAcesso aberto (Open Access)Farmacocinética da associação de glucosamina e sulfato de condroitina em humanos sadios do sexo masculino(Sociedade Brasileira de Ortopedia e Traumatologia, 2005-01-01) Toffoletto, Odaly; Tavares, Agostinho [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Redublo, Beata Marie [UNIFESP]; Ribeiro, Artur Beltrame [UNIFESP]; Fundação Oswaldo Ramos Hospital do Rim e Hipertensão; Universidade Federal de São Paulo (UNIFESP)Osteoarthrosis is a chronic joint disease that, once patent, leads to a progressive functional disability. As proteochondroitin sulfates are the major contents of the cartilage, it is expected that the ingestion of glucosamine and chondroitin might improve the biological status of that tissue. As we could not find any studies on the pharmacokinetic profile of this association by oral administration route in human beings, the objective of this study was to evaluate it by using the association of glucosamine sulfate (GS) and chondroitin sulfate (CS) given to two groups of twelve healthy male volunteers (group I: one capsule containing 500 mg of GS and 400 mg of CS; group II: four capsules with the same content). Blood samples were collected at pre-determined time intervals up to 48 hours post-dosing. GS and CS were measured in plasma by the DMMB (1,9,dimethyl-dimethilene blue) method. Maximum concentration was achieved within 2 hours (average ± SE; 0.893±0.093 µg/ml, group I; and 2.222±0.313 µg/ml, group II). Areas under curve up to 48 hours were 10.803±0.965 µg-hr/ml and 38.776±2.981 µg-hr/ml for groups I and II, respectively. Both groups showed a second peak after 18 hours, indicating an enterohepatic flow. Our results indicate that this association is absorbed through the oral route by a saturable mechanism, which can enable its use in clinical treatments.
- ItemSomente MetadadadosUrinary glycosaminoglycans in horse osteoarthritis. Effects of chondroitin sulfate and glucosamine(Elsevier B.V., 2012-08-01) Baccarin, Raquel Yvonne Arantes; Machado, Thais S. L.; Lopes-Moraes, Ana P.; Vieira, Fabiana A. C. [UNIFESP]; Michelacci, Yara M. [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Our objectives were to characterize the urinary excretion of glycosaminoglycans (GAGs) in horse osteoarthritis, and to investigate the effects of chondroitin sulfate (CS) and glucosamine (GlcN) upon the disease. Urinary GAGs were measured in 47 athletic horses, 20 healthy and 27 with osteoarthritis. the effects of CS and GlcN were investigated in mild osteoarthritis. in comparison to normal, urinary GAGs were increased in osteoarthritis, including mild osteoarthritis affecting only one joint. Treatment with CS + GlcN led to a long lasting increase in the urinary CS and keratan sulfate (KS), and significant improvement in flexion test of tarsocrural and metacarpophalangeal joints was observed. in conclusion, urinary CS and KS seems to reflect the turnover rates of cartilage matrix proteoglycans, and the measurement of these compounds could provide objective means of evaluating and monitoring joint diseases. (C) 2011 Elsevier B.V. All rights reserved.