Navegando por Palavras-chave "Gvhd Ocular"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Aspectos Clínicos, Inflamatórios E Qualidade De Vida Da Doença Do Enxerto Versus Hospedeiro Ocular
    (Universidade Federal de São Paulo (UNIFESP), 2018-09-27) Abud, Tulio Batista [UNIFESP]; Sousa, Luciene Barbosa De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    This Thesis Focuses In A Broad Evaluation Of Ocular Graft Versus Host Disease (Gvhd), Describing Clinical Aspects, Inflammatory Mechanisms, A New Therapy Option And Quality Of Life. Three Clinical Studies Were Performed (4.1), (4.2) And (4.3). Clinical Study (4.1). Objective: To Investigate The Levels Of Neutrophil Enzymes In Tears Washes Of Patients With Ocular Gvhd And Patients With No Disease. Methods: Tear Washes Were Analyzed Using Elisa And Correlations Between The Groups Were Performed For Each Enzyme Analyzed. Results: Concentrations Of Four Enzymes With Neutrophilic Source [Neutrophil Elastase (En), Myeloperoxidase (Mpo) And Metalloproteinases (Mmp"S) 8 And 9] Were Statistically Greater In Patients With Ocular Gvhd As Compared With Controls. In Addition, There Was Strong Correlation Between Them. Conclusion: Neutrophil Activity Is Present In Tears Washes Of Ocular Gvhd, Especially Because Of The Enzyme Neutrophil Elastase. Clinical Study (4.2). Objectives: To Assess The Vision-Related Quality Of Life