Navegando por Palavras-chave "Habitual abortion"

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    Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy
    (Associação Paulista de Medicina - APM, 1997-08-01) Daher, Silvia [UNIFESP]; Fonseca, Flavia [UNIFESP]; Mattar, Rosiane [UNIFESP]; Musatti, Chloe Camba [UNIFESP]; Gerbase-Lima, Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    INTRODUCTION: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE: Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD: Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. RESULTS: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. CONCLUSION: MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients.
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    Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion
    (Elsevier B.V., 2011-01-01) Traina, Evelyn [UNIFESP]; Daher, Silvia [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Sun, Sue Yazaki [UNIFESP]; Franchim, Camila Sommerauer [UNIFESP]; Mattar, Rosiane [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Hormonal, inflammatory and vascular alterations during pregnancy are thought to be involved in pregnancy loss. the role of progesterone, the actions of which involve cytokines and vascular endothelial growth factor (VEGF), has been thoroughly studied. Genetic factors are involved in modulation of these molecules, and several genes have been associated with recurrent spontaneous abortion (RSA), as well other obstetric conditions. Here we investigate the relationship between RSA and gene polymorphisms of the progesterone receptor (PROGINS), interleukin-1 receptor 1 (PstI) and vascular endothelial growth factor (VEGF) (-634, 936). This case-controlled study comprised a total of 89 women with idiopathic RSA and a control group of 191 women with at least two successful pregnancies and no miscarriages. Genomic DNA was extracted from whole blood, and polymorphism genotyping was conducted by digesting PCR products with specific restriction endonucleases. No correlations were found in any of the investigated polymorphisms, even among dominant, co-dominant and additive inheritance models and alleles. Our results support the hypothesis that these specific gene polymorphisms are not the major determinant of pregnancy success. Although we did not find any correlations, the investigation of these and other polymorphisms remains a challenge in the evaluation of RSA. (C) 2010 Elsevier Ireland Ltd. All rights reserved.