Navegando por Palavras-chave "Hemorrhagic effect"

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    A heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activity
    (Elsevier B.V., 2013-04-15) Andrade, Giuliana Paiva Viana de; Lima, Marcelo Andrade de [UNIFESP]; Souza Junior, Airton Araujo de [UNIFESP]; Fareed, Jawed; Hoppensteadt, Debra A.; Santos, Elizeu Antunes dos; Chavante, Suely Ferreira; Oliveira, Fernanda Wanderley de; Rocha, Hugo Alexandre de Oliveira; Nader, Helena Bonciani [UNIFESP]; Univ Fed Rio Grande do Norte; Universidade Federal de São Paulo (UNIFESP); Univ Liverpool; Inst Fed Rio Grande Norte; Loyola Med Sch
    A natural heparin-like compound isolated from the crab Goniopsis cruentata was structurally characterized and its anticoagulant and hemorrhagic activities were determined. Enzymatic and nuclear magnetic resonance analysis revealed that its structure is rich in disulfated disaccharides, possessing significant amounts of 2-O-sulfated-beta-D-glucuronic acid units. Furthermore, low amounts of trisulfated disaccharide units containing 2-O-sulfated-alpha-L-iduronic acid were detected, when compared to mammalian heparin. in addition, this heparin-like structure showed negligible in vitro anticoagulant activity and low bleeding potency, facts that make it a suitable candidate for the development of structure-driven, heparin based therapeutic agents with fewer undesirable effects. (C) 2013 Elsevier B.V. All rights reserved.