Navegando por Palavras-chave "Immunosuppressive drugs"

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    Growth of children born to renal transplanted women
    (Springer, 2017) Dinelli, M. Isabel S. [UNIFESP]; Ono, Erika [UNIFESP]; Viana, Patricia O. [UNIFESP]; dos Santos, Amelia M. N. [UNIFESP]; Isabel de Moraes-Pinto, M. [UNIFESP]
    Neonates born to transplanted mothers are exposed to immunosuppressive drugs during gestation and have a higher risk of being born prematurely and small for gestational age than the general population. We have prospectively followed up 27 children born to renal transplanted mothers from a single center and 31 healthy children born at term with adequate weight for gestational age. Comparisons of weight and length measurements were made at birth, 1 month (+/- 0.9), 3 months (+/- 1.0), 6 months (+/- 1.0), 9 months (+/- 1.5), and 12 months (+/- 1.49) of age. There were a high rate of prematurity (51.9%) and neonates small for gestational age (40.7%) in the transplant group. At birth, in the transplant group, 28% of neonates had subnormal z-scores for weight and 40%, low z-scores for length. However, at 6 months of age, no significant differences were noticed in mean weight-for-age z-scores between groups (weight -0.43 vs -0.03
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    Indoleamine 2,3-dioxygenase (IDO) Activity in Placental Compartments of Renal-Transplanted Pregnant Women
    (Wiley-Blackwell, 2014-07-01) Prado, Karen Matias do; Correa-Silva, Simone; Oliveira, Leandro Gustavo; Saraiva Camara, Niels Olsen; Ono, Erica [UNIFESP]; Sandri, Silvana; Tourino, Melissa Cavalheiro; Campa, Ana; Lima, Larissa de Sa; Scavone, Cristoforo; Bevilacqua, Estela; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Problem Immunosuppressive drugs change gestational IDO activity at the maternal-fetal interface. Method of Study Analysis of placental IDO expression and activity, interferon gamma (IFN-), and IL-10 expression and NFkB activity in renal transplant recipient women under immunosuppressive treatment. Results We demonstrated a significant reduction in IDO activity (P=0.0275) and expression (P=0.026) and in NFkB activity (P=0.0176) in the villous region of renal transplanted mother. These findings did not correlate with the higher serum levels of kynurenine (P=0.002). in the decidual compartment, IDO was immunolocalized mainly on the extravillous cytotrophoblast but did not show significant differences among the experimental groups; kynurenine was significantly higher (P=0.036) and was inversely proportional to the decidual IFN- profile (P=0.0433). No change was seen in IL-10 levels. NFkB activity was significantly higher in decidual compartment correlating with the higher IDO activity and suggesting that in immunosuppressant pregnancy, IDO activity and expression remain regulated by NFkB. Conclusion the increased IDO activity in decidua may indicate an attempt to offset the low expression. These findings call attention to the relevance of IDO activity at the maternal interface in pregnant transplant recipients, likely modulated by immunosuppressive agents and associated with a high risk of associated gestational disorders.