Navegando por Palavras-chave "Impaired glucose tolerance"

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    Dietary fructose, fruits, fruit juices and glucose tolerance status in Japanese-Brazilians
    (Elsevier B.V., 2009-02-01) Sartorelli, D. S.; Franco, L. J.; Gimeno, S. G. A. [UNIFESP]; Ferreira, S. R. G.; Cardoso, M. A.; Japanese Brazilian Diabet Study Gr [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Background and aims: Evidence suggests that fructose and sweetened beverages may be a risk factor for obesity and type 2 diabetes, but the role of sweetened fruit juices in glucose disturbances has been minimally explored. the aim of this study was to examine the association of total fructose, fresh fruit and sweetened fruit juice intake with glucose tolerance homeostasis in Japanese-Brazilians.Methods and results: A total of 475 men and 579 women aged >= 30 years were evaluated in a cross-sectional population-based survey with a standardized protocol including a 2-h oral glucose tolerance test (WHO criteria). Habitual food consumption was obtained using a validated food frequency questionnaire for Japanese-Brazitians. After adjustments for potential confounding variables, the odds ratio (OR; 95%Cl) for impaired glucose tolerance was 2.1 (1.0-4.5; P for trend = 0.05) for the highest as compared to the lowest tertile intake of total fructose and 2.3 (1.1-5.1; P for trend = 0.05) for the highest as compared to the lowest tertile intake of sweetened fruit juices.Conclusion: Our results showed that high intakes of dietary fructose and sweetened fruit juices, but not whole fresh fruits, were associated with impaired glucose tolerance among genetically susceptible individuals. (C) 2008 Elsevier B.V. All rights reserved.
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    Performance of glycated haemoglobin (HbA1c) as a screening test for diabetes and impaired glucose tolerance (IGT) in a high risk population-The Brazilian Xavante Indians
    (Elsevier B.V., 2014-11-01) Franco, L. J.; Dal Fabbro, A. L.; Martinez, E. Z.; Sartorelli, D. S.; Silva, A. S.; Soares, L. P.; Franco, L. F. [UNIFESP]; Kuhn, P. C. [UNIFESP]; Vieira-Filho, J. P. B. [UNIFESP]; Moises, R. S. [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Aims: To examine the properties of HbA1c to detect diabetes and IGT in adult Brazilian Xavante Indians, a high risk population for diabetes.Methods: the survey was carried out between October 2010 and January 2012 and based on a 75 g oral glucose tolerance test (OGTT). Basal and 2 h capillary glycaemia were measured by HemoCue Glucose 201+; HbA1c using an automated high-performance liquid chromatography analyzer (Tosoh G7).Results: 630 individuals aged >20 years were examined and 80 had a previous diagnosis of diabetes. Sensitivity, specificity and accuracy for HbA1c >= 6.5% (>= 48 mmol/mol) were 71.3%, 90.5% and 87.2%. the areas under the ROC curve (AUC) was 0.88 (95%CI: 0.83-0.93). To identify IGT, HbA1c values between 5.7% and 6.4% (39-47 mmol/mol) presented sensitivity, specificity and accuracy of 87.2%, 24.7% and 51.4%, with an AUC of 0.62 (95%CI: 0.57-0.67).Conclusions: the ADA/WHO proposed cut-off of 6.5% (48 mmol/mol) for HbA1c was adequate to detect diabetes among the Xavante. However, the performance of the ADA proposed cutoff points for pre-diabetes, when used to detect IGT was inadequate and should not be recommended. (C) 2014 Elsevier Ireland Ltd. All rights reserved.