Navegando por Palavras-chave "Infecções por papilomavírus"

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    Association between human Papillomavirus and colorectal adenocarcinoma and its influence on tumor staging and degree of cell differentiation
    (Colégio Brasileiro de Cirurgia Digestiva, 2014-09-01) Picanço-Junior, Olavo Magalhães; Oliveira, Andre Luiz Torres; Freire, Lucia Thereza Mascarenhas; Brito, Rosangela Baia; Villa, Luisa Lina; Matos, Delcio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Ophyr Loiola Hospital; Institute at the Oswaldo Cruz German Hospital
    BACKGROUND:Colorectal cancer is one of the most common types of neoplasia among the worldwide adult population. Among neoplasms of the gastrointestinal tract, it is ranked second in relation to prevalence and mortality, but its etiology is only known in around 5% of the cases. It is believed that 15% of malignant diseases are related to viral oncogenesis.AIM:To correlate the presence of HPV with the staging and degree of cell differentiation among patients with colorectal adenocarcinoma.METHODS:A retrospective case-control study was conducted on 144 patients divided between a test group of 79 cases of colorectal cancer and a control group to analyze 144 patients aged 25 to 85 years (mean, 57.85 years; standard deviation, 15.27 years and median, 58 years). Eighty-six patients (59.7%) were male. For both groups, tissue samples from paraffin blocks were subjected to DNA extraction followed by the polymerase chain reaction using generic and specific primers for HPV 16 and 18. Dot blot hybridization was also performed with the aim of identifying HPV DNA.RESULTS:The groups were shown to be homogenous regarding sex, age and site of HPV findings in the samples analyzed. Out of the 41 patients with HPV, 36 (45.6%) were in the cases and five (7.7%) were in the control group (p<0.001). All the HPV cases observed comprised HPV 16, and HPV 18 was not shown in any of the cases studied. There were no significant differences in comparisons of sex, age and site regarding the presence of HPV in either of the groups. It was not observe any significant difference in relation to staging or degree of cell differentiation among the patients with colorectal cancer.CONCLUSION:Human papillomavirus type 16 is present in individuals with colorectal carcinoma. However, its presence was unrelated to staging or degree of differentiation.
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    Caracterização clínica e histopatológica e tipagem do papilomavírus humano das verrugas vulgares nos receptores de transplante renal
    (Sociedade Brasileira de Dermatologia, 2010-10-01) Martelli-Marzagão, Flavia [UNIFESP]; Yamashiro, Alberto Shodi [UNIFESP]; Ogawa, Marilia Marufuji [UNIFESP]; Santos Jr, Gildo Francisco dos; Tomimori, Jane [UNIFESP]; Porro, Adriana Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Associação Fundo de Incentivo à Psicofarmacologia
    The prevalence of skin lesions caused by the human papillomavirus (HPV) is high in kidney transplant patients. Twenty recipients of kidney transplants with a diagnosis of common warts were evaluated. HPV detection was performed by polymerase chain reaction (PCR) using the MY09/MY11 and RK91 primers. HPV typing was performed by restriction fragment length polymorphism analysis and direct sequencing. The presence of HPV was identified in 10 patients (50%) and the types identified were HPV-2, 27, 29, 34 and 57.
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    Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas
    (Sociedade Brasileira de Dermatologia, 2011-04-01) Leto, Maria das Graças Pereira; Santos Júnior, Gildo Francisco dos; Porro, Adriana Maria [UNIFESP]; Tomimori, Jane [UNIFESP]; AFIP Medicina Laboratorial; Universidade Federal de São Paulo (UNIFESP)
    Human papillomavirus (HPV) is a DNA virus that presents tropism for epithelial cells, causing infections of the skin and mucous membranes. Replication of HPV occurs in the nuclei of squamous cells and its life cycle is directly related to the differentiation program of the host cell. To date, nearly 100 different types of HPV have been characterized and there is a large number of other types that have not been sequenced yet. Besides being responsible for benign lesions of the skin and mucous membranes, HPV is also involved in the development of various mucocutaneous tumors: Bowen's disease, non-melanoma skin cancers and genital carcinomas. This review discusses the characteristics of HPV, malignant and benign mucous and skin manifestations caused by HPV, besides the main methods of detection and typing of the virus.