Navegando por Palavras-chave "Interleukin"

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    Avaliação do efeito da pregabalina pré-operatória para analgesia e concentrações plasmáticas de interleucina 6, 8 e 10 após nefrectomia por lombotomia. Estudo clínico randomizado duplo-encoberto.
    (Universidade Federal de São Paulo (UNIFESP), 2018-10-25) Santiago, Ana Ellen de Queiroz [UNIFESP]; Sakata, Rioko Kimiko [UNIFESP]; Leal, Plinio da Cunha [UNIFESP]; http://lattes.cnpq.br/2150178332757393; http://lattes.cnpq.br/9796401471904195; http://lattes.cnpq.br/8078969063032908; São Paulo; Universidade Federal de São Paulo (UNIFESP)
    Background and Objectives: Pregabalin is an anticonvulsant, modulator of alpha2delta subunit of calcium channels, promoting inhibition of excitatory neurotransmitters release. It is possible that the pre-operatory administration of pregabalin promotes analgesic effect and act on release of cytokines. The objective of the study was to evaluate the analgesic effect of pregabalin after nephrectomy. Methods: A randomized double-blind study was performed in 40 patients submitted to nephrectomy for kidney transplantation. Group-1 patients received 300mg of pregabalin before the surgery and group-2 received placebo. Epidural anesthesia was performed with 15 mL of 0.5% ropivacaine followed by general anesthesia with fentanyl (3 μg.kg-1), propofol, atracurium, 50% oxygen, without nitrous oxide, and sevoflurane. There were evaluated: pain intensity after 6 and 24 hours; pain threshold with algometer periincisional and in the tennar eminence of the hand; dosage of IL 6, 8 and 10 before surgery and 6 and 24 h after a surgical incision; number of patients needing complementation; time for complementation; supplemental analgesic dose (tramadol); and adverse effects. Results: Pain intensity was lower after 24h with pregabalin, in G1; there was no difference of pain threshold with algometer in the tennar region; There were no differences between groups about IL-6, IL-8 and IL-10, after 6 and 24h; There were no differences in number of patients needing complementation, and dose of analgesic. There was no difference in the incidence of adverse effects (nausea, vomiting, headache, dizziness, agitation and pruritus). Conclusions: The administration of a single dose of 300mg of pregabalin before lombotomy decreased the intensity of pain after 24h; did not reduce supplemental analgesic dose; did not change the concentration of IL6, IL8 and IL10; did not change the incidence of adverse effects.
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    Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer
    (Associação Brasileira de Divulgação Científica, 2011-10-01) López, R.v.m.; Zago, M.a.; Eluf-Neto, J.; Curado, M.p.; Daudt, A.w.; Da Silva-Junior, W.a.; Zanette, D.l.; Levi, J.e.; De Carvalho, M.b.; Kowalski, Luiz Paulo [UNIFESP]; Abrahão, Márcio [UNIFESP]; De Góis-Filho, J.f.; Boffetta, P.; Wünsch-filho, V.; Universidade de São Paulo (USP); Registro de Câncer de Base Populacional de Goiânia Hospital Araújo Jorge; World Health Organization International Agency for Research on Cancer; Hospital de Clínicas de Porto Alegre Departamento de Oncologia; Hospital Heliópolis Departamento de Cirurgia de Cabeça e Pescoço; Hospital do Câncer A.C. Camargo Departamento de Cirurgia de Cabeça e Pescoço; Universidade Federal de São Paulo (UNIFESP); Instituto do Câncer Arnaldo Vieira de Carvalho Departamento de Cirurgia de Cabeça e Pescoço; Mount Sinai School of Medicine The Tisch Cancer Institute; International Prevention Research Institute
    The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.
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    Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori
    (Biomed Central Ltd, 2014-04-23) Caleman Neto, Agostinho; Rasmussen, Lucas T.; Labio, Roger W. de; Queiroz, Valdeir F. de; Smith, Marilia de A. C. [UNIFESP]; Viani, Gustavo A.; Payao, Spencer L. M.; Marilia Med Sch FAMEMA; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); FAMEMA
    Background: Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. the genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. the aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. the DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples.Results: H. pylori was detected in 30/60 patients (50%) by PCR. As for polymorphism of interleukin 8 (-251) gene we observed a statistical difference when analyzed TA (p = 0.039) and TT (p = 0.047) genotypes. in the IL1B31 there was a statistical difference in TT (p = 0.01) genotype and in the IL1B-511 there wasn't any statistical difference.Conclusion: Our results suggest a strong correlation between the presence of chronic gastritis and infection by H. pylori and that IL1B-31TT and IL8-251TT genotypes appear to act as protective factors against H. pylori infection while IL8-251TA genotype may comprise a risk factor for infection with this bacterium.
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    Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori
    (Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, 2014-05-20) Caleman Neto, Agostinho; Rasmussen, Lucas Trevizani [UNIFESP]; Lábio, Roger Willian de; Queiroz, Valdeir F de; Smith, Marilia de Arruda Cardoso [UNIFESP]; Viani, Gustavo A; Payão, Spencer Luiz Marques [UNIFESP]; Marília Medical School FAMEMA Blood Center Department of Genetics; Sacred Heart University; Marília Medical School Department of Digestive System Surgery; Universidade Federal de São Paulo (UNIFESP); Marília Medical School Department of Radiotherapy and Oncology; FAMEMA Hemocentro Laboratório de Genética
    Background: Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. The genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. The aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. The DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples. Result: H. pylori was detected in 30/60 patients (50%) by PCR. As for polymorphism of interleukin 8 (-251) gene we observed a statistical difference when analyzed TA (p = 0.039) and TT (p = 0.047) genotypes. In the IL1B31 there was a statistical difference in TT (p = 0.01) genotype and in theIL1B-511 there wasn’t any statistical difference. Conclusion: Our results suggest a strong correlation between the presence of chronic gastritis and infection byH. pylori and that IL1B-31TT and IL8-251TT genotypes appear to act as protective factors againstH. pylori infection while IL8-251TA genotype may comprise a risk factor for infection with this bacterium.
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    Genetic variants in gastric cancer: Risks and clinical implications
    (Academic Press Inc Elsevier Science, 2017) Gigek, Carolina Oliveira [UNIFESP]; Calcagno, Danielle Queiroz; Rasmussen, Lucas Trevizani; Santos, Leonardo Caires [UNIFESP]; Leal, Mariana Ferreira [UNIFESP]; Wisnieski, Fernanda [UNIFESP]; Burbano, Rommel Rodriguez; Lourenco, Laercio Gomes [UNIFESP]; Lopes-Filho, Gaspar Jesus [UNIFESP]; Cardoso Smith, Marilia Arruda [UNIFESP]
    Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC.
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    The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6-174GC, IL-8-251AT and MCP-1-2518AG in the risk of venous thromboembolism: A case-control study
    (Elsevier B.V., 2011-09-01) Matos, Marinez Farana [UNIFESP]; Lourenco, Dayse M. [UNIFESP]; Orikaza, Cristina M. [UNIFESP]; Bajerl, Joao A. H. [UNIFESP]; Noguti, Maria A. E. [UNIFESP]; Morelli, Vania M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Cytokines increased the risk of venous thromboembolism (VTE) in some case-control studies, but not in a prospective study. Data concerning the role of cytokines in the risk of VTE are limited. We examined in a case-control study the association of VTE and levels of interleukin (IL)-6, IL-8 and monocyte chemotactic protein-1 (MCP-1) and assessed whether promoter polymorphisms (IL-6 -174GC, IL-8 -251AT, MCP-1 -2518AG) would affect the thrombotic risk and cytokine levels.Materials and methods: the study included 119 patients (94 women) with a first event of VTE aged between 18-60 years, and 126 healthy controls (100 women) matched for age (+/- 5 years). Blood was collected >7 months after the thrombotic event. Odds ratios (ORs) were calculated per increase of cytokines levels by 1 pg/mL.Results: ORs adjusted for age and sex were 1.520 [95% Confidence Interval (CI) 1.177 - 1.962] for IL-6, 1.095 (95% CI 1.002 - 1.196) for IL-8 and 1.000 (0.988 - 1.012) for MCP-1. With additional adjustment for ethnic composition, body mass index (BMI) and high sensitive C-reactive protein (hs-CRP), risk estimates remained significant for IL-6 and became of borderline statistical significance for IL-8. Polymorphisms did not influence the thrombotic risk and the cytokine levels in study participants.Conclusion: VTE was associated with IL-6 and IL-8 levels, and for IL-6 this association was independent of BMI and hs-CRP. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are warranted. (C) 2011 Elsevier B.V. All rights reserved.