Navegando por Palavras-chave "Intestinal Mucosa"

Agora exibindo 1 - 3 de 3
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    ESTUDO DA MUCOSA ENTERALDE RESERVATÓRIOS EM J EM CÃES
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 1998-07-01) Moraes, Sandra Pedroso de; Nigro, Amaury José Teixeira [UNIFESP]; Reis Neto, José Alfredo Dos; Quilici, Flávio Antonio; Silva, Miralva Aparecida De Jesus; PUCCAMP; Universidade Federal de São Paulo (UNIFESP)
    Total proctocolectomy with enteral reservoir is, at present, the best technique used for the surgical treatment of some large intestine diseases involving the whole colon. In order to study the characteristics of the J reservoir enteral mucosa, thirty-six dogs underwent surgery. After resection of 5cm of the jejunum caudalis the animals were divided into two equal groups (GI and GII) for study-control. In GI, an entero-enteral end-to-end anastomosis was performed; in GII, a J reservoir was performed in the cranialis segment of the jejunum and this pouch was anastomosed end-to-end to the jejunun caudalis (similar to GI). On the 21st, 42nd and 63rd postoperative days, six animals of each group were sacrificed for macro and microscopic studies, including cellular counting and the measuring of the enteral mucosa lamina propria. On the 21st day, both groups showed oedema and erythema on macroscopic examination, and necrosis under microscopy in similar numbers. On the 42nd and 63rd days, these alterations decreased or disappeared in GI and persisted in GII. Only in the latter group, on macroscopy, ulcers were observed on the 21st day (2 dogs) and on the 42nd day (1 dog). In both groups there was no significant difference as to the incidence of abscess under microscopy. On the 21st day there was an increase of the volumetric density of neutrophils polymorph, macrophages, eosinophils, plasma cells and lymphocites in both groups. All the cells, except the eosinophils, showed a significant enlargement of the volumetric density in GII on the 63rd day. The transversal diameter of lamina propria, except for the villi height, was significantly larger in GII on the 63rd postoperative day. It was concluded that the enteral mucosa of the J reservoir in dogs shows alterations of the normal pattern of macroscopy and microscopy, including the volumetric density enlargement of the inflammatory cells.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Estudo do teste farmacológico com acetilcolina e cloreto de bário como monitor funcional do jejuno e de ileo, com e sem mucosa e após preservação em ratos: estudo "in vitro"
    (Universidade Federal de São Paulo (UNIFESP), 1994) Taha, Murched Omar [UNIFESP]; Koh, Ivan Hong Jun [UNIFESP]
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Histologia quantitativa como ferramenta diagnóstica da doença celíaca em crianças e adolescentes
    (Universidade Federal de São Paulo (UNIFESP), 2021) Vargas, Mateus Mendonca [UNIFESP]; Sdepanian, Vera Lucia [UNIFESP]; Universidade Federal de São Paulo
    Objective: To measure the villous height, crypt depth and the number of lymphocytes in 100 enterocytes from the small intestinal mucosa of children and adolescents with celiac disease; and classify these findings using Q- Marsh and Q-histology scales. Methods: Retrospective study from Pathologic Anatomy Department data base which analyzed biopsies from the second portion of the duodenum of three groups: celiac disease at the diagnosis (n=50), controls (n=26) and giardiasis (n=10). In each biopsy, it was evaluated 5 villous height, 5 crypt depth and the number of lymphocytes between 100 enterocytes by specialized software (cellSens and Image J). Results: The villous height mean (197,83μm) and villous:crypt ratio (0,78) of the celiac group was significantly lower than the control group (397,04 μm and 1,06 respectively). Intraepithelial lymphocytosis ≥25 was the quantitative parameter with higher sensibility and specificity (100%) to differentiate the celiac group from others. Only celiac patients were included in types 2 and 3 of Q-histology classification. Conclusion: Children and adolescents with celiac disease have shorter villous than other groups, and intraepithelial lymphocytosis is the best parameter to differentiate celiac from controls and patients with giardiasis. The presence of intraepithelial lymphocytosis ≥25/100 enterocytes and some degree of villous atrophy, the classic Marsh 3 denomination, comprises the best parameter for the diagnosis of celiac disease. The quantitative histology consists in a useful tool for the diagnosis of celiac disease and the Q-histology scale is more suitable to the studied population than Q-Marsh.