Navegando por Palavras-chave "Kidney Transplant Recipients"

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    Comparação Entre Everolimo E Micofenolato De Sódio Em Receptores De Transplante Renal Com Doadores Falecidos De Critérios Expandidos
    (Universidade Federal de São Paulo (UNIFESP), 2018-12-04) Ferreira, Alexandra Nicolau [UNIFESP]; Silva Junior, Helio Tedesco [UNIFESP]
    Introduction. The Use Of Expanded Criteria Donors (Ecd) For Kidney Transplantation Has Been A New Strategy To Increase The Number Of Deceased Donor Kidneys Available In The World. However, The Incidence Of Delayed Graft Function (Dgf), Acute Rejection And Nephrotoxic Events Is More Often In Ecd Kidneys Recipients Than Standard Criteria Donor Kidneys Recipients. The Optimal Immunosuppressive Regimen For Recipients Of Ecd Kidneys Has Not Been Defined. Methods. In This Single-Center Study, 171 Recipients Of Ecd Kidney Transplants Were Randomized To Receive Antithymocyte Globulin Induction, Delayed Introduction Of Reduced Dose Tacrolimus, Prednisone And Everolimus (R-Atg/Evr, N=88) Or Mycophenolate (R-Atg/Mps, N=83). No Cytomegalovirus (Cmv) Pharmacological Prophylaxis Was Used. The Primary End-Point Was The Incidence Of Cmv Infection/Disease In The Intention-To-Treat Population At 12 Months. Secondary Endpoints Included Treatment Failure (First Biopsy Proven Acute Rejection [Bpar], Graft Loss Or Death) And Safet
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    Comparison of the direct fluorescence assay and real-time polymerase chain reaction for the detection of influenza virus A and B in immunocompromised patients
    (Faculdade de Medicina / USP, 2013-09-01) Perosa, Ana Helena Sitta [UNIFESP]; Watanabe, Aripuanã Sakurada Aranha [UNIFESP]; Guatura, Sandra Baltazar [UNIFESP]; Silva, Ellen Ricci Monteiro da [UNIFESP]; Granato, Celso Francisco Hernandes [UNIFESP]; Bellei, Nancy Cristina Junqueira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: This study evaluated the diagnostic performance of two methods for the detection of influenza virus in immunocompromised transplant patients. METHODS: A total of 475 respiratory samples, 236 from patients in a hematopoietic stem cell transplantation program and 239 from kidney transplant patients, were analyzed by a direct fluorescence assay and the Centers for Disease Control real-time polymerase chain reaction protocol for influenza A and B detection. RESULTS: Influenza detection using either method was 7.6% in the hematopoietic stem cell transplant group and 30.5% in the kidney transplant patient group. Influenza detection by real-time polymerase chain reaction yielded a higher positive rate compared with fluorescence than that reported by other studies, and this difference was more pronounced for influenza A. The fluorescence assay sensitivity, specificity, positive and negative predictive values, and kappa coefficient were 17.6%, 100%, 1, 0.83, and 0.256, respectively, and lower detection rates occurred in the kidney transplant patients. CONCLUSIONS: The real-time polymerase chain reaction performance and the associated turnaround time for a large number of samples support the choice of this method for use in different routine diagnostic settings and influenza surveillance in high-risk patients.