Navegando por Palavras-chave "Leukoaraiosis"

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    Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology
    (Elsevier B.V., 2009-08-15) Grinberg, Lea Tenenholz; Amaro Junior, Edson; Silva, Alexandre Valotta da [UNIFESP]; Silva, Rafael Emidio da; Sato, Joao Ricardo; Santos, Denis Dionizio dos; Pacheco, Silmara de Paula; Lucena Ferretti, Renata Eloah de; Paraizo Leite, Renata Elaine; Pasqualucci, Carlos Augusto; Teipel, Stefan J.; Flatz, Wilhelm H.; Heinsen, Helmut; Brazilian Aging Brain Study Grp; Univ Wurzburg; Universidade de São Paulo (USP); Inst Israelita Ensino & Pesquisa Albert Einstein; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do ABC (UFABC); Univ Rostock; Univ Munich
    The histopathological counterpart of white matter hyperintensities is a matter of debate. Methodological and ethical limitations have prevented this question to be elucidated.We want to introduce a protocol applying state-of-the-art methods in order to solve fundamental questions regarding the neuroimaging-neuropathological uncertainties comprising the most common white matter hyperintensities [WMHs] seen in aging. By this protocol, the correlation between signal features in in situ, post mortem MRI-derived methods, including DTI and MTR and quantitative and qualitative histopathology can be investigated. We are mainly interested in determining the precise neuroanatomical substrate of incipient WMHs. A major issue in this protocol is the exact co-registration of small lesion in a tridimensional coordinate system that compensates tissue deformations after histological processing.The protocol is based on four principles: post mortem MRI in situ performed in a short post mortem interval, minimal brain deformation during processing, thick serial histological sections and computer-assisted 3D reconstruction of the histological sections.This protocol will greatly facilitate a systematic study of the location, pathogenesis, clinical impact, prognosis and prevention of WMHs. (C) 2009 Elsevier B.V. All rights reserved.