Navegando por Palavras-chave "MIB-1"

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    Associação entre tamanho e potencial proliferativo em neurinomas do acústico
    (Academia Brasileira de Neurologia - ABNEURO, 2006-03-01) Tella, Oswaldo Inácio de [UNIFESP]; Stávale, João Norberto [UNIFESP]; Herculano, Marco Antonio [UNIFESP]; Paiva Neto, Manoel Antonio de [UNIFESP]; Onishi, Franz Jooji [UNIFESP]; Guimarães Filho, Francisco de Assis Vaz [UNIFESP]; Silva, Luciano Ricardo França e [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hospital Professor Edmundo Vasconcelos; Faculdade de Medicina de Jundiaí
    Acoustic neuromas are the most common tumors in the cerebellopontine angle. The molecular mechanisms involved in generation and growth of these tumors are not completly elucidated. Many radiological, clinic and imunohistochemystry data were correlated to tumor growth. We studied 11 acoustic neuromas surgically treated at Hospital São Paulo/UNIFESP and correlated clinical and radiological data with proliferative index (Ki-67). The size of the tumors were positively correlationated with proliferative index. No other correlation had statistic significativity.
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    Gemistocytes in astrocytomas: Are they a significant prognostic factor?
    (Springer, 2006-10-01) Martins, Dely C.; Malheiros, Suzana M.; Santiago, Lucila H.; Stavale, Joao N.; Universidade Federal de São Paulo (UNIFESP)
    Our aim was to retrospectively evaluate the influence of gemistocytic astrocytes, cellular proliferation indices, immunoexpression of proteins p53 and bcl-2 in the clinical outcome of 39 patients with WHO grade II and III astrocytomas with the presence of gemistocytes. the mean proportion of gemistocytes was 18.7% and the mean proliferative index was 3.3%. Immunoexpression of p53 was detected in 29 cases (74.4%) and all cases (100%) were positive for bcl-2. the median overall survival was 97.2 months and the progression-free survival was 43.1 months. Estimated 1-, 5- and 10-year overall survival rates were 94.3%, 69.5% and 46.4%; 1-, 5- and 10-year progression-free survival rates were 91.1%, 26.1% and 13.1%. Out of 24 who presented clinical and neuroimaging worsening, characterized as tumor progression or recurrence, 16 had histological confirmation and were also analyzed. We could not detect significant differences when comparing all the indices between WHO grade II and III and also between the first and second biopsies. We also could not detect significant differences in progression-free and overall survival when analyzing the gemistocyte index and the immunohistochemical labeling indices p53, bcl-2 and MIB-1, as well as patients' age (median value, up to 34 vs. over 34 years) and histological grade (II or III). Our finding confirms recent reports that question the role of gemistocytes as a prognostic factor in diffuse astrocytomas. the significance and role of gemistocytes in astrocytomas has yet to be defined and warrants further study.
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    Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review
    (Maney Publishing, 2010-12-01) Pires de Aguiar, Paulo Henrique; Aires, Rogerio; Laws, Edward R.; Isolan, Gustavo Rassier; Logullo, Angela [UNIFESP]; Patil, Chirag; Katznelson, Laurence; Universidade de São Paulo (USP); Santa Casa de Londrina Hosp; Brigham & Womens Hosp; Univ Fed Rio Grande do Sul; Universidade Federal de São Paulo (UNIFESP); Stanford Univ
    Objective: the present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary adenomas. Although atypical adenomas are characterized by their atypical morphological features by an elevated mitotic index, a Ki-67 (MIB-1) labeling index greater than 3% and extensive nuclear staining for p53, use of the proliferation index (LI) of pituitary adenomas in assessing the degree of tumor aggressiveness is a controversial topic in the literature, and there are disparate results involving many studies.Methods: A review of literature was carried out to correlate the role of Ki-67 LI and its correlation with clinical findings, tumor size, invasiveness, recurrence, adenoma subtype, adenoma doubling time, and pituitary carcinomas is addressed. Results: the prognosis cannot be predicted on the basis of the Ki-67 LI alone. Although there is no direct relation between Ki-67 LI and some of these variables and controversial data were found regarding some topics, our review justify the use of Ki-67 in the analysis of pituitary adenomas as an additional information for clinical decision.Conclusion: Although assessment of proliferative may be helpful in predicting subsequent tumor recurrence or invasiveness, there are many other important and as yet unidentified factors pituitary tumors. It is clear that further research is needed to clarify these molecular mechanisms to predict those with a potentially poor clinical outcome.
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    Proliferation rate of intracranial meningiomas as defined by the monoclonal antibody MIB-1 - Correlation with peritumoural oedema and other clinicoradiological and histological characteristics
    (Springer, 2003-07-01) Aguiar, P. H.; Tsanaclis, A. M.; Tella, O. I.; Plese, J. P.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Paraffin-embedded surgical specimens from 55 meningiomas were immunostained after microwave processing using the streptavidin/peroxidase method and the monoclonal antibody (moAb) MIB-1 to the Ki-67 antigen. the authors assessed proliferative labelling index (LI) from a series of surgically removed meningiomas using immunohistochemical methods and MIB-1, and they correlated this index with clinical, radiological, and histological factors. No relationship was found between LI, sex, age, resection and histological grades, or volume. Symptoms, location, and peritumoural oedema did have a significant relationship to the MIB-1 LI. the symptomatic patients, i.e. those with tumours at the base of the skull and with GR3 peritumoural oedema (grade 3), had a greater chance of higher MIB-1 LI. It was proven that the increase of one unit in peritumoural oedema classification gave an increased risk of 3.312 and an LI greater than 3%. the authors also discuss the different methods of evaluating LIs in meningiomas, based on the available literature.