Navegando por Palavras-chave "Marker"

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    Can breast tumors affect the oxidative status of the surrounding environment? A comparative analysis among cancerous breast, mammary adjacent tissue, and plasma
    (Hindawi ltd, 2016) Panis, C.; Victorino, V. J.; Herrera, A. C. S. A.; Cecchini, A. L.; Simao, A. N. C.; Tomita, L. Y. [UNIFESP]; Cecchini, R.
    In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-alpha and nitric oxide.
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    Índice triglicerídeo-glicose como preditor para doenças cardiovasculares em pacientes com diabetes tipo 2: uma revisão sistemática
    (Universidade Federal de São Paulo, 2024-08-23) Mota, Alexia Correia [UNIFESP]; Pereira, Edimar Cristiano [UNIFESP]; Fonseca, Fernando Luiz Affonso; http://lattes.cnpq.br/6772382797320564; http://lattes.cnpq.br/0781717751741554
    Em um contexto mundial, onde a população está vivendo cada vez mais, a longevidade saudável é vista como um dos aspectos mais importantes dentro das populações. Para que este aspecto seja atendido, doenças crônicas vêm sendo cada vez mais estudadas para que haja um tratamento preventivo e eficaz, evitando assim a morte precoce dos indivíduos. Neste sentido, muitos estudos concentram suas pesquisas na prevenção de doenças que podem ser causadas devido à comorbidades já existentes, como a dislipidemia, em pacientes diabéticos tipo 2. Estudos recentes trazem a relação entre eventos cardiovasculares adversos com dislipidemia e diabetes tipo 2. O intuito destes é descobrir marcadores promissores que auxiliem os pacientes a escaparem dos desfechos desfavoráveis existentes destas doenças. Desta forma, a revisão sistemática desta monografia tem o objetivo de reunir artigos científicos que trazem o índice triglicerídeo-glicose como potencial indicador de risco de doenças cardiovasculares, o qual encontra-se alterado em pacientes diabéticos com dislipidemia. Na análise do índice, proposta por um exame de sangue nos estudos contidos nesta monografia, simplifica a identificação dos possíveis riscos de doenças cardiovasculares futuras, proporcionando a possibilidade de tratamentos medicamentosos e preventivos direcionados na mudança de estilo de vida do indivíduo. A adição deste marcador nos exames laboratoriais das populações do mundo impactará positivamente na longevidade dos pacientes que possuem diabetes tipo 2, uma das maiores doenças crônicas do século XXI.
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    Predictors of Recurrence of Ovarian Granulosa Cell Tumors
    (Lippincott Williams & Wilkins, 2009-05-01) Nosov, Vladimir; Silva, Ivaldo [UNIFESP]; Tavassoli, Fattaneh; Adamyan, Leiva; Farias-Eisner, Robin; Schwartz, Peter E.; Univ Calif Los Angeles; Universidade Federal de São Paulo (UNIFESP); Yale New Haven Med Ctr; Kulakov Sci Ctr Obstet Gynecol & Perinatol
    Objective: the prognosis of granulosa cell tumors (GCTs) is overall favorable, but a proportion of patients will experience recurrence. We report one of the largest series of patients with GCT for whom clinical, morphologic, and immunohistochemical markers have been assessed for their roles as predictors of recurrence.Methods: Patients with the diagnosis of GCT were identified at 2 hospitals from 1974 to 2004; a detailed chart analysis was performed. Tissue blocks were analyzed immunohistochemically for mitotic index, luteinization, inhibin staining, epidermal growth factor receptor, and Ki67 expression. Univariate and multivariate analyses were performed.Results: Sixty-seven patients were identified. Follow-up data up to 30 years were available. the mean age at diagnosis was 48.1 years. Twenty-five patients experienced recurrence. A statistically significant correlation (P < 0.05) was observed for age at diagnosis, with earlier age being an adverse factor (43.6 vs 50.9, P < 0.01), and use of adjuvant chemotherapy postoperatively (24% vs 40% in the nonrecurrence group). Luteinization and the immunohistochemical markers, such as inhibin, Ki67, and epidermal growth factor receptor, seemed to significantly increase the risk of recurrence if expressed. A multivariate analysis model confirmed that younger age at diagnosis and higher expression of inhibin and Ki67 are significant risk factors of GCT recurrence.Conclusions: Identification of patients who are at a high risk for recurrence of GCT is critical. Routine treatment for all patients with cytotoxic chemotherapy is not justified. We report a set of predictors of recurrence for GCT that identified subsets of patients who may benefit from prolonged surveillance and/or adjuvant systemic chemotherapy.
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    Serum endocan levels associated with hypertension and loss of renal function in pediatric patients after two years from renal transplant
    (Dove Medical Press Ltd, 2016) de Souza, Livia Victorino [UNIFESP]; Oliveira, Vanessa [UNIFESP]; Laurindo, Aline Oliveira [UNIFESP]; Huarachi, DelmaRegina Gomes [UNIFESP]; Koch Nogueira, Paulo Cesar [UNIFESP]; Feltran, Luciana de Santis [UNIFESP]; Medina-Pestana, Jose Osmar [UNIFESP]; Franco, Andmaria do Carmo [UNIFESP]
    Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients' blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: r = 0.416