Navegando por Palavras-chave "Melanized fungi"

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    Challenges in the Therapy of Chromoblastomycosis
    (Springer, 2013-06-01) Queiroz-Telles, Flavio; Santos, Daniel Wagner de C. L. [UNIFESP]; Univ Fed Parana; Universidade Federal de São Paulo (UNIFESP); Inst Infect Dis Emilio Ribas
    Chromoblastomycosis (CBM) is an implantation mycosis mainly occurring in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long-term therapy with systemic antifungals flanked by various physical treatment regimens. As in other neglected endemic mycoses, comparative clinical trials have not been performed for this disease; nowadays, therapy is mainly based on a few open trials and on expert opinions. Itraconazole, either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been employed successfully in combination with antifungals in patients presenting with CBM. in the present paper, the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.
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    Melanized fungal infections in kidney transplant recipients: contributions to optimize clinical management
    (Elsevier Sci Ltd, 2017) Santos, D. W. [UNIFESP]; Camargo, L. P. [UNIFESP]; Goncalves, S. S. [UNIFESP]; Ogawa, M. M.; Tomimori, J. [UNIFESP]; Enokihara, M. M.; Medina-Pestana, J. O.; Colombo, A. L. [UNIFESP]
    Objectives: This is a retrospective and observational study addressing clinical and therapeutic aspects of melanized fungal infections in kidney transplant recipients. Methods: We retrospectively reviewed medical records of all patients admitted between January 1996 and December 2013 in a single institution who developed infections by melanized fungi. Results: We reported on 56 patients aged between 30 and 74 years with phaeohyphomycosis or chromoblastomycosis (0.54 cases per 100 kidney transplants). The median time to diagnosis post-transplant was 31.2 months. Thirty-four (60.8%) infections were reported in deceased donor recipients. Fifty-one cases of phaeohyphomycosis were restricted to subcutaneous tissues, followed by two cases with pneumonia and one with brain involvement. Most dermatological lesions were represented by cysts (23/51