Navegando por Palavras-chave "Memory retrieval"

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    M1 muscarinic receptors are necessary for retrieval of remote context fear memory
    (Pergamon-Elsevier Science Ltd, 2017) Patricio, Rafael Rodisanski [UNIFESP]; Kramer Soares, Juliana Carlota [UNIFESP]; Menezes Oliveira, Maria Gabriela [UNIFESP]
    Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28 days, the rats received dicyclomine (16 or 32 mg/lcg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32 mg/kg dicydomine induced impairment of CFC. In TFC task only the performance of the rats 28 days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory. (C) 2016 Elsevier Inc. All rights reserved.
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    Sleep deprivation impairs emotional memory retrieval in mice: Influence of sex
    (Elsevier B.V., 2012-08-07) Fernandes-Santos, Luciano [UNIFESP]; Patti, Camilla de Lima [UNIFESP]; Zanin, Karina Agustini [UNIFESP]; Fernandes, Helaine Arrais [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The deleterious effects of paradoxical sleep deprivation on memory processes are well documented. However, non-selective sleep deprivation occurs more commonly in modern society and thus represents a better translational model. We have recently reported that acute total sleep deprivation (TSD) for 6 h immediately before testing impaired performance of male mice in the plus-maze discriminative avoidance task (PM-DAT) and in the passive avoidance task (PAT). in order to extend these findings to females, we examined the effect of (pre-test) TSD on the retrieval of different memory tasks in both male and female mice. Animals were tested using 3 distinct memory models: 1) conditioning fear context (CFC), 2) PAT and 3) PM-DAT. in all experiments, animals were totally sleep-deprived by the gentle interference method for 6 h immediately before being tested. in the CFC task and the PAT, TSD induced memory impairment regardless of sex. in PM-DAT, the memory impairing effects of TSD were greater in females. Collectively, our results confirm the impairing effect of TSD on emotional memory retrieval and demonstrate that it can be higher in female mice depending on the memory task evaluated. (C) 2012 Elsevier Inc. All rights reserved.