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    Recommendations of the Brazilian Society of Rheumatology for the induction therapy of ANCA-associated vasculitis
    (Elsevier Science Inc, 2017) Silva de Souza, Alexandre Wagner [UNIFESP]; Calich, Ana Luisa [UNIFESP]; Mariz, Henrique de Ataide; Gomes Ochtrop, Manuella Lima; Santos Bacchiega, Ana Beatriz; Ferreira, Gilda Aparecida; Rego, Jozelia; Perez, Mariana Ortega; Rodrigues Pereira, Rosa Maria; Bernardo, Wanderley Marques; Levy, Roger Abramino
    The purpose of these recommendations is to guide the appropriate induction treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients with active disease. The recommendations proposed by the Vasculopathies Committee of the Brazilian Society Rheumatology for induction therapy of AAV, including granulomatosis with polyangiitis, microscopic polyangiitis and renal-limited vasculitis, were based on systematic literature review and expert opinion. Literature review was performed using Medline (PubMed), EMBASE and Cochrane database to retrieve articles until October 2016. PRISMA guidelines were used for the systematic review and articles were assessed according to the Oxford levels of evidence. Sixteen recommendations were made regarding different aspects of induction therapy for AAV. The purpose of these recommendations is to serve as a guide for therapeutic decisions by health care professionals in the management of AAV patients presenting active disease. (c) 2017 Published by Elsevier Editora Ltda.