Navegando por Palavras-chave "Multivitamin"

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    Caracterização dos efeitos adversos de agroquímicos isolados ou combinados e estudo do potencial protetivo de suplemento polivitaminico em ratos machos juvenis
    (Universidade Federal de São Paulo (UNIFESP), 2019-06-17) Garcia, Mariana Simoes [UNIFESP]; Perobelli, Juliana Elaine [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Agrochemicals are the most widely used synthetic chemicals in the world. They have the function of minimizing pests that interfere with the production of the vast majority of agricultural crops. Since 2009, Brazil is the country that uses the biggest amount agrochemicals in the world. Residues from these products contaminates food, soil and water, leading to environmental exposure for the entire world population. Under real conditions, this exposure occurs to complex mixtures of agrochemicals, which may establish synergistic or additive effects to each other, enhancing or adding the consequent health damage. An important pathway of these chemicals is oxidative damage to cellular components generated by excess of free radicals due to an imbalance between the production of these reactive molecules and the natural antioxidant system. In this way, the consumption of multivitamins supplements can be used as a way to increase the antioxidant defense of the organism, mitigating the adverse effects of these toxic agents. In fact, some studies have been investigated thevinjuries caused by chemical mixtures in experimental models, as well as the protective effect of antioxidant agents, but the vast majority uses adult individuals. In this context, the importance of juvenile / pre-pubertal toxicity studies has been highlighted in the recent literature because it is a period of great sensitivity during postnatal development. Given the scarcity of studies and the relevance of the issue, the present study aims to investigate whether pre-pubertal exposures at low doses of Carbendazim, Acefato and Mancozebe, because they are present in greater quantity in the diet of Brazilians, alone or in a mixture, cause immediate repercussions on the reproductive and endocrine parameters of juvenile male Wistar rats. In addition, it evaluates the potential protective effect of co-administration of multivitamins and minerals supplement. For this purpose, rats were exposed to the agrochemicals alone or in mixture (binary or triple) with or without supplementation, orally by gavage, from the postnatal day 23 to 53, when they were euthanized and evaluated for the histomorphometric parameters of testis and epididymis. Serum levels of steroid hormones were evaluated. In summary, the results indicate likely endocrine disrupting action of agrochemicals. Interestingly, isolated agrochemicals appear to exert more pronounced adverse effects than when administered in mixture. However, the group treated with multivitamin supplement did not present a significant protective effect as a form of protection against toxicological effects.