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- ItemAcesso aberto (Open Access)Crescimento de cristais marinhos de NaCl para análises da Luminescência Opticamente Estimulada (LOE)(Universidade Federal de São Paulo, 2022-02-08) Lucena, Julia Vieira [UNIFESP]; Rocca, René Rojas [UNIFESP]; http://lattes.cnpq.br/3055041079988241; http://lattes.cnpq.br/0314283113127813; Universidade Federal de São Paulo (UNIFESP)O presente trabalho teve como principal objetivo estudar uma nova técnica para a sinterização de cristais de Cloreto de Sódio (NaCl) obtidos diretamente da água do mar, com a finalidade de obter-se uma luminescência eficiente, um melhor controle na quantidade de amostra a ser utilizada, uma maior distribuição dos cristais em uma alíquota, e também verificar sua aplicabilidade como dosímetro, com os testes de requisitos dosimétricos. O sal comum é um material que já tem sido estudado no meio da dosimetria, pois apresenta uma alta sensibilidade quando exposto à radiação ionizante podendo assim ser utilizado na dosimetria luminescente. Com o intuito de realizar o crescimento dos cristais marinhos com baixo custo e fácil fabricação, foi efetuada a pulverização da solução concentrada de água do mar sobre discos de 1 cm de alumínio reciclado a 70 ºC, com esse procedimento obtivemos alíquotas homogêneas, com cristais crescidos uniformemente, e desse modo, conseguimos realizar a produção de várias alíquotas em uma única fabricação com as mesmas características. Sabendo que o sal possui propriedade higroscópica, impermeabilizamos com base em esmalte comercial. Para analisar a estrutura cristalina formada com esta nova técnica, utilizamos a difração de raios x (DRX) e foi atestada a formação da estrutura do cloreto de sódio. Para as medidas LOE, usamos o leitor RISØ TL/LOE (modelo TL/OSL-DA-20) por estímulo de luz azul (470 nm) com uma fonte beta 90Sr/90Y (estrôncio e ítrio) acoplado ao leitor, primeiramente foi feito o tratamento térmico nas alíquotas a 400 ºC, em diferentes tempos, 2 h, 24 h e 48 h para observar o efeito no sinal LOE, nas medidas LOE as alíquotas foram irradiadas com uma dose de 162 mGy, com pré-aquecimento de 160 ºC durante 1 s, posteriormente uma medição com uma temperatura assistida de 110 ºC e estimuladas por 40 s com a luz azul. Para as análises dos testes de requisito dosimétrico, realizamos o teste de linearidade e obtivemos uma resposta linear das intensidades LOE entre 81 a 1000 mGy, na reprodutibilidade tivemos uma variação de apenas 4% em 70 medidas consecutivas, na avaliação do fading comparamos alíquotas com e sem tratamento térmico, e vemos um decaimento mínimo na amostra com tratamento térmico.
- ItemSomente MetadadadosEarly developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage(Springer Heidelberg, 2016) Araujo, I. C. [UNIFESP]; Andrade, R. P.; Santos, F.; Soares, E. S.; Yokota, R. [UNIFESP]; Mostarda, C.; Fiorino, P.; De Angelis, K.; Irigoyen, M. C.; Morris, M.; Farah, V. [UNIFESP]Metabolic syndrome (MS) increases the risk of type 2 diabetes and cardiovascular disease. High consumption of fructose is a proposed cause of increased MS, manifested through hypertension, obesity, insulin resistance, and dyslipidemia. High NaCl also increases the risk of CD. The purpose of this study is to evaluate the influence of fructose and sodium on autonomic dysfunction and its relation with CD in MS. Fructose overload was started at weaning and continued through adulthood. Male Wistar rats (21 days) were divided into four groups: Control (C), fructose consumption (10 %, F), NaCl consumption (salt 1 % for the 10 last days, S), and fructose and NaCl (FS), and monitored for 8 weeks. Metabolic evaluations consisted of Lee index, glycemia, insulin and glucose tolerance tests, triglycerides, and total cholesterol measurements. Cardiovascular parameters measured were arterial pressure (AP) and cardiac function performed by echocardiography. They also measured the influence of renin angiotensin (RAS) and autonomic nervous systems by drug blockage with losartan, atropine, and atenolol. Energy analysis showed no change between groups. Fructose overload induced a MS state, confirmed by insulin resistance, glucose intolerance, and dyslipidemia. Fasting glucose was increased in F and FS rat groups compared with C and S groups. AP was higher in F, S, and FS groups in comparison with the C group. The hypotensive response after sympathetic blockade was increased in F, S, and FS versus C. The cardiac vagal tonus was reduced in F and FS animal groups. The intrinsic heart rate was decreased in the FS group (372 +/- A 9 bpm) compared with the C group (410 +/- A 13 bpm). The morphometric measurements evaluated through left ventricular diameter during diastole and the left ventricular diameter during systole decreased in the FS group (16 and 26 %, respectively). Diastolic function was reduced in F and FS. The depressor response induced by losartan was increased in the F group in comparison with other groups. However, there was a uniform increase in plasma ACE activity in all treated groups compared with the C group. Data suggest that early exposure to high fructose intake produced marked alterations in metabolic and cardiovascular function. When stimulated by NaCl, the fructose-fed subjects showed further impairment in cardiac function.
- ItemSomente MetadadadosEarly developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage(Springer Heidelberg, 2016) Araujo, I. C. [UNIFESP]; Andrade, R. P.; Santos, F.; Soares, E. S.; Yokota, R. [UNIFESP]; Mostarda, C.; Fiorino, P.; De Angelis, K.; Irigoyen, M. C.; Morris, M.; Farah, V. [UNIFESP]Metabolic syndrome (MS) increases the risk of type 2 diabetes and cardiovascular disease. High consumption of fructose is a proposed cause of increased MS, manifested through hypertension, obesity, insulin resistance, and dyslipidemia. High NaCl also increases the risk of CD. The purpose of this study is to evaluate the influence of fructose and sodium on autonomic dysfunction and its relation with CD in MS. Fructose overload was started at weaning and continued through adulthood. Male Wistar rats (21 days) were divided into four groups: Control (C), fructose consumption (10 %, F), NaCl consumption (salt 1 % for the 10 last days, S), and fructose and NaCl (FS), and monitored for 8 weeks. Metabolic evaluations consisted of Lee index, glycemia, insulin and glucose tolerance tests, triglycerides, and total cholesterol measurements. Cardiovascular parameters measured were arterial pressure (AP) and cardiac function performed by echocardiography. They also measured the influence of renin angiotensin (RAS) and autonomic nervous systems by drug blockage with losartan, atropine, and atenolol. Energy analysis showed no change between groups. Fructose overload induced a MS state, confirmed by insulin resistance, glucose intolerance, and dyslipidemia. Fasting glucose was increased in F and FS rat groups compared with C and S groups. AP was higher in F, S, and FS groups in comparison with the C group. The hypotensive response after sympathetic blockade was increased in F, S, and FS versus C. The cardiac vagal tonus was reduced in F and FS animal groups. The intrinsic heart rate was decreased in the FS group (372 +/- A 9 bpm) compared with the C group (410 +/- A 13 bpm). The morphometric measurements evaluated through left ventricular diameter during diastole and the left ventricular diameter during systole decreased in the FS group (16 and 26 %, respectively). Diastolic function was reduced in F and FS. The depressor response induced by losartan was increased in the F group in comparison with other groups. However, there was a uniform increase in plasma ACE activity in all treated groups compared with the C group. Data suggest that early exposure to high fructose intake produced marked alterations in metabolic and cardiovascular function. When stimulated by NaCl, the fructose-fed subjects showed further impairment in cardiac function.