Navegando por Palavras-chave "Nitric oxid"

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    Atividade vasomotora simpática renal e esplâncnica em um modelo de hipertensão por inibição da síntese de óxido nítrico
    (Universidade Federal de São Paulo (UNIFESP), 2016-02-29) Zambrano, Lysien Ivania [UNIFESP]; Bergamaschi, Cassia Marta de Toledo [UNIFESP]; http://lattes.cnpq.br/1166526138293050; http://lattes.cnpq.br/9986923610490402; Universidade Federal de São Paulo (UNIFESP)
    Systemic hypertension is a multifactorial disease. Among several factors that contributes to the increase in blood pressure, it highlights the deficiency of nitric oxide (NO) and changes in sympathetic vasomotor activity (SNA). The role of NO in the modulation of autonomic function is still controversial in the literature. This work aimed to study the association of sympatoexcitation with inhibition of NO synthesis-induced hypertension. Thus, the present study evaluated the SNA for two different beds, splanchnic and renal (rSNA and sSNA), mean arterial pressure (MAP), heart rate (HR), arterial baroreceptor control for both territories, as well as possible correlations between these parameters and the plasma levels of NO. After eight days of treatment with N-nitro-L-arginine methyl ester (L-NAME - 20mg / kg / day by gavage), a NO sintase inhibitor, obtain 50% increase in MAP, no change in HR, 29% increase in rSNA and 97% sSNA, as well as an increased response to depressing of arterial baroreceptors. Plasma levels of NO were reduced 31% in animals treated with LNAME. Taken altogether, our results demonstrate that inhibition of NO synthesis promotes major hemodynamic changes and autonomic control improvement to different regions innervated by the sympathetic nerves and it is likely that these changes were caused by reduced NO levels both systemically and within brain regions of autonomic control.
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    Avaliação da correlação entre o controle clínico da asma, os valores de função pulmonar e o grau de inflamação das vias aéreas em crianças e adolescentes com asma
    (Universidade Federal de São Paulo (UNIFESP), 2014-11-28) Chaves, Danielle Maria de Souza [UNIFESP]; Wandalsen, Gustavo Falbo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objectives: to evaluate in children and adolescents relations among four asthma characteristics: values of exhaled nitric oxide (FeNO), lung function, bronchodilator response (BR) and the degree of asthma control; to describe FeNO values in this population of asthmatics and to study the influence of clinical, demographic and functional aspects. Methods: cross-sectional evaluation of 147 children and adolescents with asthma followed in a reference out-patient clinic measuring FeNO values, spirometry, BR, asthma control questionnaire (ACT or C-ACT) and clinical data. Results: median age was 12.2 years (6 to 18 years) and 92 were males. Median from the time since the last asthma exacerbation was three months. Median of BMI z score was 0.73z and 122 patients had some associated disease, predominating allergic rhinitis (101 patients) and atopic dermatitis (42 patients). Ninety nine patients were in regular use of asthma control medication for at least one month. Seventy three (50%) patients had some abnormality in lung function and 34 (24%) showed positive BR (FEV1 increase of ? 12%). Uncontrolled asthma (ACT or C-ACT ? 19) was observed in 45 (31%) cases. In the total group we observed moderate correlations only between BR values and: FEV1 (r= -0.46), FEV1/FVC (r= -0.44) and FEF25-75% (r= -0.33). Among patients without regular control treatment, FeNO values correlated significantly with FEV1/FVC (r= -0.34), FEF25-75% (r= -0.34) and ACT/C-ACT (r= -0.25). Correlations observed in patients with regular asthma control treatment were, in general, weaker than those founded in patients without control treatment. In this group, FeNO values correlated significantly only with FEV1/FVC values (r= -0.18). FeNO values ranged from 1ppb to 196ppb (median 29.9ppb) and abnormal values (> 25ppb) were found in 81 (55%) patients. Those in regular use of asthma control medication had lower values than those without it (median: 23.5ppb vs 37.0ppb; p=0.006). FeNO values correlated significantly with time since the last asthma exacerbation (r= -0.24; p=0.02) and age (r= 0.19; p=0.009). Patients, when separated according to GINA steps of treatment, showed significantly different values of FeNO (p=0.04). Patients with abnormal lung function had higher BR values (median: 9% vs 5%; p<0.01) and lower values of ACT/C-ACT (median: 20 vs 22; p=0.01). Patients with positive BR had lower values of FEV1 (median: 76% vs 95%; p<0.001), FEV1/FVC (median: 76% vs 90%; p<0.001) and FEF25-75% (median: 59% vs 88%; p<0.001) than those without positive BR response. FeNO values were higher among patients with BR response (median: 45.3ppb vs 25.4ppb; p=0.01). Patients with uncontrolled asthma showed larger BR (median: 8% vs 5%; p=0.01) but without differences in FeNO values and lung function. Conclusions: FeNO, lung function, BR and asthma control scores are variables that did not correlate strongly, probably because they represent different domains of the disease. Correlations between FeNO values and these variables were stronger among asthmatics without regular control treatment. FeNO values showed a large variability and correlated significantly with age (positive) and time since the last asthma exacerbation (negative)