Navegando por Palavras-chave "Novel environment"

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    Environmental novelty and illumination modify ethanol-induced open-field behavioral effects in mice
    (Elsevier B.V., 2010-03-01) Fukushiro, Daniela F. [UNIFESP]; Benetti, Liliane F. [UNIFESP]; Josino, Fabiana S. [UNIFESP]; Oliveira, Gabriela P. [UNIFESP]; Fernandes, Maiara deM. [UNIFESP]; Saito, Luis P. [UNIFESP]; Uehara, Regina A. [UNIFESP]; Wuo-Silva, Raphael [UNIFESP]; Oliveira, Camila S. [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Both spontaneous and drug-induced animal behaviors can be modified by exposure to novel stimuli or different levels of environmental illumination. However, research into how these factors specifically impact ethanol (ETH)-induced behavioral effects is currently lacking. We aimed to investigate the effects of these two factors, considered separately or in conjunction, on ETH-induced acute hyperloconnotor effect and its sensitization in adult male Swiss mice. Mice were placed in a novel or familiar open-field under normal light (200 lx) or low light (9 lx) immediately after receiving an ip injection of either 1.8 g/kg ETH or saline (SAL). After 7 days, all animals received an ip challenge injection of 1.8 g/kg ETH, and were placed in the open-field under the same light conditions described above. Novelty increased central locomotion and decreased grooming, while low light increased grooming. Acute ETH administration increased both total and peripheral locomotion and these effects were potentiated by low light. Both low light and novelty were able to facilitate ETH-induced locomotor sensitization, which was detected by the central locomotion parameter. However, there was no synergism between the effects of these two modulating factors on ETH-induced behavioral sensitization. We conclude that both the acute behavioral effects of ETH and behavioral sensitization induced by previous administration of this drug can be critically modified by environmental factors. in addition, our study stresses the importance of using different behavioral parameters to evaluate the interaction between environmental factors and ETH effects. (C) 2009 Elsevier Inc. All rights reserved.