Navegando por Palavras-chave "Obstructive"
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- ItemAcesso aberto (Open Access)Avaliação clínica e polissonográfica do aparelho BRD no tratamento da Síndrome da Apneia Obstrutiva do Sono(Dental Press International, 2010-02-01) Dal-fabbro, Cibele [UNIFESP]; Chaves Junior, Cauby Maia [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do CearáOBJECTIVES: The current investigation aimed to carry out a clinical and polysomnographic assessment of treatment of Obstructive Sleep Apnea Syndrome (OSAS) with an oral appliance (OA) developed and tested by two Brazilian federal universities. METHODOLOGY: The sample was composed of 50 patients (aged between 18 and 65 years, 33 men and 17 women) with initial polysomnographic diagnosis of light to moderate OSAS. All patients underwent a second, full-night polysomnography with the use of the OA approximately 6 months after the first assessment. Based on the reduction of respiratory events obtained with the OA, patients were distributed in good responders (Apnea and Hypopnea Index/AHI under 10 and with reduction of at least 50% in relation to baseline); and poor responders (AHI of 10 or over with OA). RESULTS AND CONCLUSION: In 54% of the sample, AIH reduced to less than five events/hour with OA; in 38% the AHI reduction was more than 50% in relation to baseline (but more than five); and in 6% of the sample, the AHI reduced less than 50%. Good responders corresponded to 86% of the studied sample, while poor responders to 14%. We noticed significant improvement in somnolence, in AIH, in microarousals and also in minimum oxygen saturation with the treatment. Increased body mass index (BMI) seemed to interfere unfavorably in the performance of the OA studied.
- ItemAcesso aberto (Open Access)Avaliação comportamental em crianças com disturbios obstrutivos do sono(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2006-02-01) Uema, Sandra Fumi Hamasaki [UNIFESP]; Vidal, Marla Vargas Rodrigues [UNIFESP]; Fujita, Reginaldo Raimundo [UNIFESP]; Moreira, Gustavo Antonio [UNIFESP]; Pignatari, Shirley Shizue Nagata [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)AIM: The purpose of this study was to evaluate the behavior in children with obstructive sleep disorder. STUDY DESIGN: Prospective study. MATERIAL AND METHOD: Children s parents (4 to 18 years old) completed the CBCL4/18 (Child Behavior Checklist) in the period of January to July 2005. RESULTS: In the group, 12 (60%) were males and 8 (40%) females; the total problem score was abnormal in 5 children (25%); introversion was affected in 2 children (10%); extroversion in 5 children (25%). The scales of individual syndromes were abnormal in between 0 and 20% of patients. The individual scales most frequently affected were: total competency (20%), somatic complaints (10%), social problems (10%) and aggressive behavior (10%). DISCUSSION: This study demonstrates high prevalence (25%) of abnormal behavior. Although widely reported as a common complication of pediatric OSAS, behavioral and neurocognitive disorders have mostly been inferred in several cases and studies. There are few recent studies using standardized assessment to evaluate these alterations. Our study presents preliminary results of the behavior of children with obstructive sleep disorders.
- ItemAcesso aberto (Open Access)Efeito da teofilina associada ao beta2-agonista inalatório de curta ou longa duração, em pacientes com doença pulmonar obstrutiva crônica estável: revisão sistemática(Sociedade Brasileira de Pneumologia e Tisiologia, 2007-04-01) Zacarias, Eliane Cristina [UNIFESP]; Castro, Aldemar Araujo [UNIFESP]; Cendon Filha, Sônia Perez [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVES: To determine whether, in stable patients with chronic obstructive pulmonary disease, administration of theophylline in combination with short-acting or long-acting inhaled beta2-agonists is more efficacious than is a placebo or each of these drugs used in isolation. METHODS: A systematic review and meta-analysis were carried out. All randomized and double-blind clinical trials found in the literature were selected. RESULTS: A total of eight studies were included. In comparing the effect of theophylline combined with beta2-agonists to that of a placebo, we found a statistically significant improvement in mean FEV1 (0.27 L; 95%CI: 0.11 to 0.43) and mean dyspnea (-0.78; 95%CI: -1.26 to -0.29). None of the meta-analyses performed detected any difference between the results obtained using theophylline combined with beta2-agonists and those obtained using beta2-agonists alone. When the administration of theophylline combined with beta2-agonists was compared to that of theophylline alone, there was a statistically significant improvement in mean dyspnea (-0.19; 95%CI: -0.34 to 0.04). CONCLUSION: In patients with stable chronic obstructive pulmonary disease, theophylline combined with beta2 agonists is more efficacious than is a placebo in terms of improving FEV1 and dyspnea. In addition, theophylline combined with beta2 agonists is more efficacious than is theophylline in improving dyspnea. Furthermore, administration of theophylline combined with beta2 agonists is no more efficacious, for any of the variables studied, than is the use of beta2-agonists in isolation.